Regulation of energy metabolism by receptor tyrosine kinase ligands
Metabolic diseases, such as diabetes, obesity, and fatty liver disease, have now reached
epidemic proportions. Receptor tyrosine kinases (RTKs) are a family of cell surface …
epidemic proportions. Receptor tyrosine kinases (RTKs) are a family of cell surface …
Endocrine FGFs and their signaling in the brain: Relevance for energy homeostasis
Since their discovery in 2000, there has been a continuous expansion of studies
investigating the physiology, biochemistry, and pharmacology of endocrine fibroblast growth …
investigating the physiology, biochemistry, and pharmacology of endocrine fibroblast growth …
Fibroblast growth factor signaling in metabolic regulation
VJM Nies, G Sancar, W Liu, T Van Zutphen… - Frontiers in …, 2016 - frontiersin.org
The prevalence of obesity is a growing health problem. Obesity is strongly associated with
several comorbidities, such as non-alcoholic fatty liver disease, certain cancers, insulin …
several comorbidities, such as non-alcoholic fatty liver disease, certain cancers, insulin …
Fibroblast growth factor-21, energy balance and obesity
Abstract Fibroblast growth factor (FGF)-21 is an endocrine member of the FGF family with
healthy effects on glucose and lipid metabolism. FGF21 reduces glycemia and lipidemia in …
healthy effects on glucose and lipid metabolism. FGF21 reduces glycemia and lipidemia in …
Metabolic roles of endocrine fibroblast growth factors
I Fernandes-Freitas, BM Owen - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Endocrine FGFs act via a membrane-bound FGF-receptor in complex with
α/βKlotho.•FGF15 regulates postprandial liver metabolism.•FGF21 coordinates adaptive …
α/βKlotho.•FGF15 regulates postprandial liver metabolism.•FGF21 coordinates adaptive …
Metabolic fibroblast growth factors (FGFs): mediators of energy homeostasis
KR Markan, MJ Potthoff - Seminars in cell & developmental biology, 2016 - Elsevier
The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from
classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient …
classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient …
Metabolic messengers: FGF21
KH Flippo, MJ Potthoff - Nature metabolism, 2021 - nature.com
As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …
an endocrine hormone that signals to distinct targets throughout the body. Interest in …
Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
BM Owen, DJ Mangelsdorf, SA Kliewer - Trends in Endocrinology & …, 2015 - cell.com
Fibroblast growth factors (FGFs) 15/19 and 21 belong to a subfamily of FGFs that function as
hormones. Produced in response to specific nutritional cues, they act on overlapping sets of …
hormones. Produced in response to specific nutritional cues, they act on overlapping sets of …
Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome
J Zhang, Y Li - Drug discovery today, 2014 - Elsevier
Highlights•FGF21 is an endocrine hormone that can potently regulate glucose, lipid and
energy homeostasis from rodents to non-human primates.•FGF21's primary metabolic …
energy homeostasis from rodents to non-human primates.•FGF21's primary metabolic …