Understanding how Aβ42 oligomers induce changes in neurons from a mechanobiological
perspective has important implications in neuronal dysfunction relevant to …

Small soluble species of amyloid-beta (Aβ) formed during early peptide aggregation stages
are responsible for several neurotoxic mechanisms relevant to the pathology of Alzheimer's …

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical
and hippocampal brain structures are classic hallmarks of Alzheimer's disease (AD) …

Astrocytes are known to serve as scaffolding cells that shape the brain. The physical
properties of astrocytes, such as stiffness, are important for their scaffolding function. These …

Aggregated amyloid beta (Aβ) is widely reported to cause neuronal dystrophy and toxicity
through multiple pathways: oxidative stress, disrupting calcium homeostasis, and …

Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

Because of its intimate relation with Alzheimer's disease (AD), the question of how amyloid-β
peptide (Aβ) deposition alters the membrane and cytoskeltal structure of neural cells and …

Physiological interactions between extracellular matrix (ECM) proteins and membrane
integrin receptors play a crucial role in neuroplasticity in the hippocampus, a key region …

To design and engineer materials inspired by the properties of the brain, whether for
mechanical simulants or for tissue regeneration studies, the brain tissue itself must be well …

Biomechanical cues guide proliferation, growth and maturation of neurons. Yet the
molecules that shape the brain's biomechanical properties are unidentified and the …