Living Bacteria‐Based Immuno‐Photodynamic Therapy: Metabolic Labeling of Clostridium butyricum for Eradicating Malignant Melanoma

L Shi, X Liu, Y Li, S Li, W Wu, X Gao, B Liu - Advanced Science, 2022 - Wiley Online Library
Due to the complexity, aggressiveness, and heterogeneity of malignant melanoma, it is
difficult to eradicate the whole tumor through conventional treatment. Herein, a strategy of …

Photodynamic treatment of tumor with bacteria expressing killerred

L Yan, M Kanada, J Zhang, S Okazaki, S Terakawa - PloS one, 2015 - journals.plos.org
Photodynamic therapy (PDT) is a cancer treatment modality in which a photosensitizing dye
is administered and exposed to light to kill tumor cells via the production of reactive oxygen …

Engineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatment

Z Yang, Y Zhu, Z Dong, Y Hao, C Wang, Q Li, Y Wu… - Biomaterials, 2022 - Elsevier
The limited penetration depth of external excitation light would remarkably impair the
therapeutic efficacy of photodynamic therapy (PDT) and its clinical utilization. Herein, we …

Photosensitizer-bacteria biohybrids promote photodynamic cancer cell ablation and intracellular protein delivery

M Wu, W Wu, Y Duan, X Li, G Qi, B Liu - Chemistry of Materials, 2019 - ACS Publications
Live bacteria have drawn widespread interest as carriers to deliver genes and proteins into
eukaryotic cells for the treatment of various cancer types owing to their good biocompatibility …

Photothermal Lysis of Engineered Bacteria to Modulate Amino Acid Metabolism against Tumors

M Sun, M Yang, S Li, C Wang, F Zhang… - Advanced Functional …, 2023 - Wiley Online Library
Bacterial‐mediated synergistic cancer therapy (BMSCT) is used as a promising tumor
therapy approach. However, there are some disadvantages of bacterial therapy alone to be …

Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy

H Pan, L Li, G Pang, C Han, B Liu, Y Zhang… - Chemical Engineering …, 2021 - Elsevier
Engineered anaerobic bacteria known as live biotherapeutic products (LBPs) have shown
great advances in cancer therapy. One advantage of anaerobic bacteria as drug carrier is …

Bacterial targeted AIE photosensitizers synergistically promote chemotherapy for the treatment of inflammatory cancer

T Zhang, Y Deng, SL Yang, SL Chua, BZ Tang… - Chemical Engineering …, 2022 - Elsevier
Tumor-associated components, especially extratumoral bacteria (EB) in the form of biofilms,
could exacerbate cancer progression and hinder the effectiveness of antitumor drugs by …

Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

X Liu, M Wu, M Wang, Y Duan, CU Phan, G Qi… - Materials …, 2021 - pubs.rsc.org
A living therapeutic system based on attenuated Salmonella was developed via metabolic
engineering using an aggregation-induced emission (AIE) photosensitizer MA. The …

Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy

B Chen, X Zhang, L Cheng, X Chen, J Tang… - Journal of Controlled …, 2023 - Elsevier
The use of bacteria as living vehicles has attracted increasing attentions in tumor therapy
field. The combination of functional materials with bacteria dramatically facilitates the …

Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics

X Yang, S Komatsu, S Reghu, E Miyako - Nano Today, 2021 - Elsevier
Despite the growing promise of bacterial therapy, due to the tumor targeting effect, in solid
tumor treatment, most conventional therapeutic bacteria exhibit pathogenicity and …