Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights

PH Reddy, S Kshirsagar, C Bose… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of
the aging population. RalBP1 (Rlip) is a stress-activated protein that plays a crucial role in …

[HTML][HTML] Rlip reduction induces oxidative stress and mitochondrial dysfunction in mutant tau-expressed immortalized hippocampal neurons: mechanistic insights

PH Reddy, S Kshirsagar, C Bose, JA Pradeepkiran… - Cells, 2023 - mdpi.com
RalBP1 (Rlip) is a stress-activated protein that is believed to play a large role in aging and
neurodegenerative diseases such as Alzheimer's disease (AD) and other tauopathies. The …

[HTML][HTML] RALBP1 in oxidative stress and mitochondrial dysfunction in Alzheimer's disease

S Awasthi, A Hindle, NA Sawant, M George, M Vijayan… - Cells, 2021 - mdpi.com
The purpose of our study is to understand the role of the RALBP1 gene in oxidative stress
(OS), mitochondrial dysfunction and cognition in Alzheimer's disease (AD) pathogenesis …

The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients

C Bose, S Kshirsagar, M Vijayan, S Kumar… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Several converging lines of evidence from our group support a potential role of RLIP76 (AKA
Rlip) in neurodegenerative disorders, including Alzheimer's Disease (AD). However, the role …

[HTML][HTML] Rlip76: an unexplored player in neurodegeneration and Alzheimer's disease?

A Hindle, SP Singh, JA Pradeepkiran, C Bose… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most
common cause of dementia in older people. AD is associated with the loss of synapses …

Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease

J Baig, N Sawant, P Rawat, AP Reddy… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of
the aging population. RalBP1 (Rlip) is a stress-activated protein, that plays an important role …

[HTML][HTML] Correction: Reddy et al. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons …

PH Reddy, S Kshirsagar, C Bose, JA Pradeepkiran… - Cells, 2024 - mdpi.com
Cells | Free Full-Text | Correction: Reddy et al. Rlip Reduction Induces Oxidative Stress and
Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons …

[HTML][HTML] Autophagy and LRRK2 in the aging brain

F Albanese, S Novello, M Morari - Frontiers in neuroscience, 2019 - frontiersin.org
Autophagy is a highly conserved process by which long-lived macromolecules, protein
aggregates and dysfunctional/damaged organelles are delivered to lysosomes for …

[HTML][HTML] Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway

RA Fuentealba, Q Liu, T Kanekiyo, J Zhang… - Journal of Biological …, 2009 - ASBMB
The low density lipoprotein receptor-related protein 1 (LRP1) is a multi-ligand receptor
abundantly expressed in neurons. Previous work has shown that brain LRP1 levels are …

Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification …

F Di Domenico, R Sultana, A Ferree… - Antioxidants & redox …, 2012 - liebertpub.com
Aims: The human LRRK2 gene has been identified as the most common causative gene of
autosomal-dominantly inherited and idiopathic Parkinson disease (PD). The G2019S …