Spinal cord injury results in acute as well as progressive secondary destruction of local and
distant nervous tissue through a number of degenerative mechanisms. Spinal cord injury …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Spinal cord injury (SCI) often induces loss of motor and/or sensory function below the level
of injury. While deficits persist in complete lesions, partial lesions of the spinal cord can be …

Over the past three decades, multiple mechanisms limiting central nervous system
regeneration have been identified. Here, we address plasticity arising from spared systems …

Severe spinal cord injury (SCI) leads to devastating loss of neurological function below the
level of injury and adversely affects multiple body systems. Most basic research on SCI is …

Detailed pathophysiological findings of secondary damage phenomena after spinal cord
injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded …

ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …

One of the big challenges in neuroscience that remains to be understood is why the central
nervous system is not able to regenerate to the extent that the peripheral nervous system …