Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …

Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf)
malaria and target merozoites to reduce or prevent blood-stage replication and the …

Abstract Background Antibodies targeting Plasmodium falciparum sporozoites play a key
role in human immunity to malaria. However, antibody mechanisms that neutralize …

Antibodies play major roles in immunity to malaria; however, a limited understanding of
mechanisms mediating protection is a major barrier to vaccine development. We have …

Individuals in areas of Plasmodium falciparum endemicity develop immunity to malaria after
repeated exposure. Knowledge of the acquisition and nature of protective immune …

Background Antibody-mediated complement fixation has previously been associated with
protection against malaria in naturally acquired immunity. However, the process of early-life …

Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a
major global health priority, although this has proven to be immensely challenging over the …

Background We investigated the poorly understood impact of declining malaria transmission
on maintenance of antibodies to Plasmodium falciparum merozoite antigens and infected …

Background. Elucidating the mechanisms of naturally acquired immunity to Plasmodium
falciparum infections would be highly valuable for malaria vaccine development …

Malaria vaccine design and prioritization has been hindered by the lack of a mechanistic
correlate of protection. We previously demonstrated a strong association between protection …