European Society of Sexual Medicine consensus statement on the use of animal models for studying Peyronie's disease

F Castiglione, OÖ Çakır, N Schifano, G Corona… - Sexual …, 2023 - academic.oup.com
Introduction Animal models are frequently used for translational research in Peyronie's
disease (PD). However, due to lack of availability of guidelines, there is some heterogeneity …

Laboratory forum: experimental models of Peyronie's disease. Implications for new therapies

NF Gonzalez-Cadavid, J Rajfer - The journal of sexual medicine, 2009 - academic.oup.com
Introduction Despite its high prevalence and impact on the quality of life of patients, and that
it is an excellent model for the study of fibrotic processes, Peyronie's disease (PD) is an …

Rat as an animal model for Peyronie's disease research: a review of current methods and the peer-reviewed literature

E Chung, L De Young, GB Brock - International journal of impotence …, 2011 - nature.com
While the exact mechanism of Peyronie's disease (PD) remains an enigma, the
pathophysiology of PD is considered to be multifactorial, with interactions of genetic …

(149) PD. SPHERE, a Novel Three-dimension Cellular Model for Peyronie's Disease via 'Microgravity'Condition: The New Era of in vitro Cell Culture-based Model for …

W Kiattiburut, K Feng, D Hickling… - The Journal of …, 2023 - academic.oup.com
Introduction Peyronie's disease (PD) is a common problem that affects 4-13% of the male
population and results in a significant decline in patient and partner quality of life. Currently …

(113) A Novel 3D Cellular Model for Peyronie's Disease Treatment Screening: PD. SPHERE

W Kiattiburut, K Feng, J Burton… - The Journal of Sexual …, 2024 - academic.oup.com
Introduction Peyronie's disease (PD) is a common issue that affects approximately 10% of
males. Currently, researchers primarily study the pathogenesis and potential treatments for …

Animal experimental model of Peyronie's disease: a pilot study

MA Cerruto, C D'Elia, A Molinari… - Archivio Italiano di …, 2013 - pagepressjournals.org
Objective: The Peyronie's disease (PD) is an idiopathic disorder of connective tissue of the
penis, that involves the tunica albuginea of the corpora cavernosa and the adjacent areolar …

PD48-05 FINDING THE CAUSE OF THE CURVE: DEVELOPMENT OF AN IN VITRO 3D PEYRONIE'S DISEASE MODEL

L Witherspoon, M Robinson, R Flannigan - The Journal of Urology, 2021 - auajournals.org
INTRODUCTION AND OBJECTIVE: Understanding of the pathophysiology of Peyronie's
disease is limited. A mechanistic Peyronie's disease model remains elusive, with currently …

Peyronie's disease intervention studies: an exploration of modern-era challenges in study design and evaluating treatment outcomes

MJ Ziegelmann, LW Trost, GI Russo… - The Journal of Sexual …, 2020 - academic.oup.com
Introduction Peyronie's disease (PD) is characterized by pain, deformity, sexual dysfunction,
and psychological bother. Several treatments are available with varying levels of efficacy …

244 A Systematic Review of Modeling in Peyronie's Disease

P Krishnappa, C Manfredi, D Arcaniolo… - The Journal of …, 2022 - academic.oup.com
Introduction Penile modeling to correct the penile curvature in Peyronie's disease (PD) may
be achieved manually (intra-operatively or post-injection) or by using assisted devices …

Solving a bottleneck in animal models of peyronie's disease

S Cellek, W Stebbeds, DJ Ralph - Asian Journal of Andrology, 2014 - journals.lww.com
Peyronie's disease is characterized by the formation of a fibrous plaque in the tunica
albuginea (TA) of the penis. It is a benign condition of unclear etiology, resulting in …