Elucidating the global and local rules that govern genome-wide, hierarchical chromatin
architecture remains a critical challenge. Current high-throughput chromosome …

The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called
nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped …

It has been some 40 years since repeating subunits in eukaryotic chromatin, initially termed
“nu bodies,” were described. Four decades of study have characterized the structural …

How chromatin remodelers cooperate to organize nucleosomes around the start and end of
genes is not known. We determined the genome-wide binding of remodeler complexes …

Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …

Two recent studies mapped nucleosomes across the yeast and human genomes, teasing
apart the relative contributions of DNA sequence and chromatin remodelers to nucleosome …

Although the genomic pattern of nucleosome positioning is broadly conserved, quantitative
aspects vary over evolutionary timescales. We identify the cis and trans determinants of …

Eukaryotes associate their genomes with histone proteins, forming nucleosome particles.
Nucleosomes regulate and protect the genetic information. They often assemble into evenly …

Electron micrographs first confirmed that the eukaryotic genome is organized into repeating
disk-shaped nucleosomal units composed of histones and their associated DNA. Those …

Nucleosomes in all eukaryotes examined to date adopt a characteristic architecture within
genes and play fundamental roles in regulating transcription, yet the identity and precise …