Receptor-mediated gene delivery uses specific cell surface components for pDNA uptake in
vivo and in vitro and improves therapeutic efficiency by accumulating drugs in targeted …

Gene therapy is a promising approach for the treatment of many diseases. However, the
effective delivery of the cargo without degradation in vivo is one of the major hurdles. With …

The last few years have witnessed a great advance in the development of nonviral systems
for in vivo targeted delivery of nucleic acids. Lipid nanoparticles (LNPs) are the most …

Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are
considered to be one of the most efficient drug delivery platforms. Due to the prominent …

Gene therapies have the potential to target and effectively treat a variety of diseases
including cancer as well as genetic, neurological, and autoimmune disorders. Although we …

Gene therapy has emerged as a potential platform for treating several dreaded and rare
diseases that would not have been possible with traditional therapies. Viral vectors have …

The era of nucleic acid nanomedicine has arrived, as evidenced by Patisiran, a small
interfering RNA (siRNA) encapsulated lipid nanoparticle (LNP), and mRNA-loaded LNPs …

Since their inception in the 1980s, oligonucleotide-based (ON-based) therapeutics have
been recognized as powerful tools that can treat a broad spectrum of diseases. The …

Nonviral vectors which offer a safer and versatile alternative to viral vectors have been
developed to overcome problems caused by viral carriers. However, their transfection …

Gene therapy is a technique utilized to treat diseases caused by missing, defective or
overexpressing genes. Although viral vectors transfect cells efficiently, risks associated with …