The sources of reactive oxygen species and its possible role in the pathogenesis of Parkinson's disease

M Weng, X Xie, C Liu, KL Lim, C Zhang… - Parkinson's …, 2018 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by progressive loss of dopaminergic neurons in the substantia nigra. The …

[HTML][HTML] Damage to dopaminergic neurons by oxidative stress in Parkinson's disease

JD Guo, X Zhao, Y Li, GR Li… - International …, 2018 - build.spandidos-publications.com
Oxidative stress is increasingly recognized as a central event contributing to the
degeneration of dopaminergic neurons in the pathogenesis of Parkinson's disease (PD) …

Oxidative stress and Parkinson's disease: conflict of oxidant-antioxidant systems

M Hemmati-Dinarvand, M Valilo… - Neuroscience …, 2019 - Elsevier
Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is
diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are …

Oxidative modification and its implications for the neurodegeneration of Parkinson's disease

J Zhao, S Yu, Y Zheng, H Yang, J Zhang - Molecular neurobiology, 2017 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
major characteristics of PD include the loss of dopaminergic neurons in the substantia nigra …

Astrocytic oxidative/nitrosative stress contributes to Parkinson's disease pathogenesis: the dual role of reactive astrocytes

A Rizor, E Pajarillo, J Johnson, M Aschner, E Lee - Antioxidants, 2019 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide; it is characterized by dopaminergic neurodegeneration in the substantia nigra …

Oxidative stress factors in Parkinson's disease

J Dorszewska, M Kowalska, M Prendecki… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is the second most common cause of neurodegeneration. Over the
last two decades, various hypotheses have been proposed to explain the etiology of PD …

The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms

AP Lan, J Chen, ZF Chai, Y Hu - Biometals, 2016 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease with
gradual loss of dopaminergic neurons. Despite extensive research in the past decades, the …

Oxidative stress and neuroinflammation potentiate each other to promote progression of dopamine neurodegeneration

J He, G Zhu, G Wang, F Zhang - Oxidative medicine and …, 2020 - Wiley Online Library
Parkinson's disease (PD) is a chronic and complex disease of the central nervous system
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …

Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration

W Zhang, Z Yan, J Gao, L Sun, X Huang, Z Liu… - Molecular …, 2014 - Springer
Parkinson's disease (PD) patients have excessive iron depositions in substantia nigra (SN).
Neuroinflammation characterized by microglial activation is pivotal for dopaminergic …

Oxidative and inflammatory pathways in Parkinson's disease

RL Miller, M James-Kracke, GY Sun, AY Sun - Neurochemical research, 2009 - Springer
Parkinson's disease (PD) is the second most prevalent age-related neurodegenerative
disease with physiological manifestations including tremors, bradykinesia, abnormal …