[HTML][HTML] Exosomes derived from mesenchymal stem cells modulate miR-126 to ameliorate hyperglycemia-induced retinal inflammation via targeting HMGB1

W Zhang, Y Wang, Y Kong - Investigative ophthalmology & …, 2019 - iovs.arvojournals.org
Purpose: In this study, we aim to investigate whether mesenchymal stem cell (MSC)-derived
exosomes (MSC-Exos) could regulate hyperglycemia-induced retinal inflammation by …

Adipose mesenchymal stem cells‐secreted extracellular vesicles containing microRNA‐192 delays diabetic retinopathy by targeting ITGA1

C Gu, H Zhang, Y Gao - Journal of cellular physiology, 2021 - Wiley Online Library
Diabetic retinopathy (DR) has characteristics of early loss of capillary pericytes, contributing
to aberrant endothelial proliferation and angiogenesis. The function of extracellular vesicles …

MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis

X Cao, LD Xue, Y Di, T Li, YJ Tian, Y Song - Life Sciences, 2021 - Elsevier
Aims Diabetic retinopathy (DR) is the most common complication of type 2 diabetes mellitus,
which could result in visual impairment. Accumulating studies have shown the implication of …

Bone marrow mesenchymal stem cells-induced exosomal microRNA-486-3p protects against diabetic retinopathy through TLR4/NF-κB axis repression

W Li, L Jin, Y Cui, A Nie, N Xie, G Liang - Journal of Endocrinological …, 2021 - Springer
Aim Diabetic retinopathy (DR) is a chronic disease causing health and economic burdens
on individuals and society. Thus, this study is conducted to figure out the mechanisms of …

Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-17-3p ameliorates inflammatory reaction and antioxidant injury of mice with diabetic …

W Li, L Jin, Y Cui, N Xie - International immunopharmacology, 2021 - Elsevier
Background Accumulating evidence has reported the role of microRNA (miR) on diabetic
retinopathy (DR). Thus, the aim of the study was to investigate the effect of exosomal miR-17 …

Adipose mesenchymal stem cells–derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits

A Safwat, D Sabry, A Ragiae, E Amer… - Journal of …, 2018 - journals.sagepub.com
This study aimed to evaluate the effect of mesenchymal stem cells (MSCs)–derived
exosomes in retina regeneration of experimentally induced diabetes mellitus (DM) in a …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles protect retina in a mouse model of retinitis pigmentosa by anti-inflammation through miR-146a-Nr4a3 …

J Zhang, P Li, G Zhao, S He, D Xu, W Jiang… - Stem Cell Research & …, 2022 - Springer
Background Retinitis pigmentosa is a rod-cone degenerative disease that induces
irreversible vision loss. This study probed the protective capacity of mesenchymal stem cell …

[HTML][HTML] TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p …

Z Yu, Y Wen, N Jiang, Z Li, J Guan, Y Zhang, C Deng… - Biomaterials, 2022 - Elsevier
Retinal ischemia-reperfusion injury (IRI) is one of the main pathogenic mechanisms of
glaucoma, which are largely unknown, including neuroinflammation and neuronal death in …

Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy

S Gu, Y Liu, J Zou, W Wang, T Wei, X Wang… - Experimental eye …, 2020 - Elsevier
Previous studies have reported that endothelial-to-mesenchymal transition (EndoMT)
contributes to pathological fibrosis in proliferative diabetic retinopathy (PDR). The …

Exosomes derived from platelet-rich plasma mediate hyperglycemia-induced retinal endothelial injury via targeting the TLR4 signaling pathway

W Zhang, X Dong, T Wang, Y Kong - Experimental eye research, 2019 - Elsevier
In this study, we aimed to investigate whether exosomes derived from platelet-rich plasma
(PRP-Exos) can regulate hyperglycemia-induced retinal injury via targeting the TLR4 …