Tissue refractive index as marker of disease

Z Wang, K Tangella, A Balla… - Journal of biomedical …, 2011 - spiedigitallibrary.org
The gold standard in histopathology relies on manual investigation of stained tissue
biopsies. A sensitive and quantitative method for in situ tissue specimen inspection is highly …

Tissue refractometry using Hilbert phase microscopy

N Lue, J Bewersdorf, MD Lessard, K Badizadegan… - Optics letters, 2007 - opg.optica.org
We present, for the first time to our knowledge, quantitative phase images associated with
unstained 5 μm thick tissue slices of mouse brain, spleen, and liver. The refractive properties …

[HTML][HTML] Visible to near-infrared refractive properties of freshly-excised human-liver tissues: marking hepatic malignancies

P Giannios, KG Toutouzas, M Matiatou, K Stasinos… - Scientific reports, 2016 - nature.com
The refractive index is an optical constant that plays a significant role in the description of
light-matter interactions. When it comes to biological media, refraction is understudied …

Refractive index of biological tissues: Review, measurement techniques, and applications

R Khan, B Gul, S Khan, H Nisar, I Ahmad - … and Photodynamic Therapy, 2021 - Elsevier
Refractive index (RI) is a characteristic optical variable that controls the propagation of light
in the medium (eg, biological tissues). Basic research with the aim to investigate the RI of …

Refractive index of tissue measured with confocal microscopy

JJJ Dirckx, LC Kuypers… - Journal of biomedical …, 2005 - spiedigitallibrary.org
Refractive index of tissue is an essential parameter in many bio-optical experiments, yet little
data can be found in literature. Several methods have been proposed to measure refractive …

Quantitative dispersion microscopy

D Fu, W Choi, Y Sung, Z Yaqoob, RR Dasari… - Biomedical optics …, 2010 - opg.optica.org
Refractive index dispersion is an intrinsic optical property and a useful source of contrast in
biological imaging studies. In this report, we present the first dispersion phase imaging of …

Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters

M Sun, H He, N Zeng, E Du, Y Guo, S Liu… - Biomedical optics …, 2014 - opg.optica.org
Mueller matrices can be used as a powerful tool to probe qualitatively the microstructures of
biological tissues. Certain transformation processes can provide new sets of parameters …

Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology

K Sokolov, R Drezek, K Gossage… - Optics …, 1999 - opg.optica.org
We present a method for selective detection of size-dependent scattering characteristics of
epithelial cells in vivo based on polarized illumination and polarization sensitive detection of …

Stain-free quantification of chromosomes in live cells using regularized tomographic phase microscopy

Y Sung, W Choi, N Lue, RR Dasari, Z Yaqoob - PloS one, 2012 - journals.plos.org
Refractive index imaging is a label-free technique that enables long-term monitoring of the
internal structures and molecular composition in living cells with minimal perturbation …

Quantitative refractive index distribution of single cell by combining phase-shifting interferometry and AFM imaging

Q Zhang, L Zhong, P Tang, Y Yuan, S Liu, J Tian… - Scientific reports, 2017 - nature.com
Cell refractive index, an intrinsic optical parameter, is closely correlated with the intracellular
mass and concentration. By combining optical phase-shifting interferometry (PSI) and atomic …