Nucleotides play a crucial role in extracellular signaling across species boundaries. All the
three kingdoms of life (Bacteria, Archea and Eukariota) are responsive to extracellular ATP …

ATP is a potent signaling molecule abundantly present in the CNS. It elicits a wide array of
physiological effects and is regarded as the phylogenetically most ancient epigenetic factor …

ATP is a potent signalling molecule abundantly present in the nervous system, where it
exerts physiological actions ranging from short‐term responses such as neurotransmission …

The purine ATP has a prominent regulatory role in CNS function and pathology due to its
actions on glial cells-microglia, astrocytes and oligodendrocytes. ATP serves as an …

Extracellular adenosine 5'-triphosphate (eATP) is ubiquitously used for cell-tocell
communication. The low concentration of eATP ([eATP]) that exists in a “halo” surrounding …

Abstract Adenosine 5′-triphosphate (ATP) is released as a genuine co-transmitter, or as a
principal purinergic neurotransmitter, in an exocytotic and non-exocytotic manner. It …

Astrocytes are ideally situated to integrate glial and neuronal functions and neurovascular
coupling by way of their multiple contacts with neurons, glia and blood vessels. There is a …

The principle functions of neuroinflammation are to limit tissue damage and promote tissue
repair in response to pathogens or injury. While neuroinflammation has utility …

J. Neurochem.(2011) 116, 796–805. Abstract ATP is a widespread and multipurpose
signalling molecule copiously released in the extracellular environment of the whole …

Extracellular ATP (eATP), the most abundant among nucleotides, can act as a mediator
during inflammatory responses by binding to plasmamembrane P2 purinergic receptors …