[HTML][HTML] Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

V Kostenko, O Akimov, O Gutnik, H Kostenko… - Heliyon, 2023 - cell.com
One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

[HTML][HTML] Natural coumarin derivatives activating Nrf2 signaling pathway as lead compounds for the design and synthesis of intestinal anti-inflammatory drugs

LC Di Stasi - Pharmaceuticals, 2023 - mdpi.com
Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor related to stress
response and cellular homeostasis that plays a key role in maintaining the redox system …

Oxidative stress and inflammation: what polyphenols can do for us?

T Hussain, B Tan, Y Yin, F Blachier… - Oxidative medicine …, 2016 - Wiley Online Library
Oxidative stress is viewed as an imbalance between the production of reactive oxygen
species (ROS) and their elimination by protective mechanisms, which can lead to chronic …

[HTML][HTML] The role of dietary phenolic compounds in epigenetic modulation involved in inflammatory processes

M Číž, A Dvořáková, V Skočková, L Kubala - Antioxidants, 2020 - mdpi.com
A better understanding of the interactions between dietary phenolic compounds and the
epigenetics of inflammation may impact pathological conditions and their treatment …

The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases

M Jaganjac, L Milkovic, A Gegotek, M Cindric… - Free Radical Biology …, 2020 - Elsevier
Modern analytical methods combined with the modern concepts of redox signaling revealed
4-hydroxy-2-nonenal (4-HNE) as particular growth regulating factor involved in redox …

Regulation of inflammation and redox signaling by dietary polyphenols

I Rahman, SK Biswas, PA Kirkham - Biochemical pharmacology, 2006 - Elsevier
Reactive oxygen species (ROS) play a key role in enhancing the inflammation through the
activation of NF-κB and AP-1 transcription factors, and nuclear histone acetylation and …

Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases

XL Chen, C Kunsch - Current pharmaceutical design, 2004 - ingentaconnect.com
In the last decade, it has become recognized that reactive oxygen species (ROS) play
important roles in the multiple biological processes involved in the pathophysiology of …

Pharmaco-redox regulation of cytokine-related pathways: from receptor signaling to pharmacogenomics

JJ Haddad - Free Radical Biology and Medicine, 2002 - Elsevier
Cytokines represent a multi-diverse family of polypeptide regulators; they are relatively low
molecular weight (< 30 kDa), pharmacologically active proteins that are secreted by one cell …

[HTML][HTML] Regulation of inflammatory reaction in health and disease

M Fioranelli, MG Roccia, D Flavin, L Cota - International journal of …, 2021 - mdpi.com
Inflammation is a key mechanism for the clearance of infective agents and other
inflammatory triggers and is pivotal for the repairing processes of the affected tissues …

An overview of the advantages of KEAP1-NRF2 system activation during inflammatory disease treatment

N Keleku-Lukwete, M Suzuki… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: Inflammation can be defined as a protective immune response against harmful
exogenous and endogenous stimuli. Nevertheless, prolonged or autoimmune inflammatory …