Physicochemical determinants in the cellular responses to nanostructured amorphous silicas

E Gazzano, M Ghiazza, M Polimeni, V Bolis… - Toxicological …, 2012 - academic.oup.com
Amorphous silicas, opposite to crystalline polymorphs, have been regarded so far as
nonpathogenic, but few studies have addressed the toxicity of the wide array of amorphous …

The nanosilica hazard: another variable entity

D Napierska, LCJ Thomassen, D Lison… - Particle and fibre …, 2010 - Springer
Silica nanoparticles (SNPs) are produced on an industrial scale and are an addition to a
growing number of commercial products. SNPs also have great potential for a variety of …

Subtoxic cell responses to silica particles with different size and shape

M Kersting, M Olejnik, N Rosenkranz, K Loza… - Scientific Reports, 2020 - nature.com
Health risks from particles are a priority challenge to health protection at work. Despite the
ubiquitous exposure to a wide range of particles and the many years of research in this field …

[HTML][HTML] The toxicological mode of action and the safety of synthetic amorphous silica—A nanostructured material

C Fruijtier-Pölloth - Toxicology, 2012 - Elsevier
Synthetic amorphous silica (SAS), in the form of pyrogenic (fumed), precipitated, gel or
colloidal SAS, has been used in a wide variety of industrial and consumer applications …

Cytotoxic and genotoxic evaluation of different synthetic amorphous silica nanomaterials in the V79 cell line

Y Guichard, C Fontana, E Chavinier… - Toxicology and …, 2016 - journals.sagepub.com
The nature of occupational risks and hazards in industries that produce or use synthetic
amorphous silica (SAS) nanoparticles is still under discussion. Manufactured SAS occur in …

Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines

R Foldbjerg, J Wang, C Beer, K Thorsen… - Chemico-biological …, 2013 - Elsevier
Much of the concerns regarding engineered nanoparticle (NP) toxicity are based on
knowledge from previous studies on particles in ambient air or occupational situations. Eg …

Repeated vs. acute exposure of RAW264. 7 mouse macrophages to silica nanoparticles: a bioaccumulation and functional change study

A Torres, B Dalzon, V Collin-Faure, T Rabilloud - Nanomaterials, 2020 - mdpi.com
Synthetic amorphous silica is used in various applications such as cosmetics, food, or
rubber reinforcement. These broad uses increase human exposure, and thus the potential …

The size-dependent cytotoxicity of amorphous silica nanoparticles: a systematic review of in vitro studies

X Dong, Z Wu, X Li, L Xiao, M Yang, Y Li… - International journal …, 2020 - Taylor & Francis
With the increasing production and application of engineered amorphous silica
nanoparticles (aSiNPs), people have more opportunities to be exposed to aSiNPs. However …

Silica-induced cytokine release from A549 cells: importance of surface area versus size

RB Hefland, PE Schwarzel… - Human & …, 2001 - journals.sagepub.com
Physical and chemical properties such as structure, composition and surface reactivity
determine the biological activity of mineral particles. Long-term exposureto crystalline silica …

In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line

JS Chang, KLB Chang, DF Hwang… - Environmental science & …, 2007 - ACS Publications
Amorphous silica is increasingly used in diagnostic and biomedical research because of its
ease of production and relatively low cost. It is generally regarded as safe and has been …