Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
A decade of molecular biology of retinoic acid receptors
P Chambon - The FASEB journal, 1996 - Wiley Online Library
Retinoids play an important role in development, differentiation, and homeostasis. The
discovery of retinoid receptors belonging to the superfamily of nuclear ligand‐activated …
discovery of retinoid receptors belonging to the superfamily of nuclear ligand‐activated …
[HTML][HTML] Retinoids as chemo-preventive and molecular-targeted anti-cancer therapies
VO Hunsu, COB Facey, JZ Fields… - International Journal of …, 2021 - mdpi.com
Retinoic acid (RA) agents possess anti-tumor activity through their ability to induce cellular
differentiation. However, retinoids have not yet been translated into effective systemic …
differentiation. However, retinoids have not yet been translated into effective systemic …
Nuclear retinoid receptors and the transcription of retinoid-target genes
J Bastien, C Rochette-Egly - Gene, 2004 - Elsevier
The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and
RXRs) which are ligand-activated transcription factors. In response to retinoid binding …
RXRs) which are ligand-activated transcription factors. In response to retinoid binding …
Diverse actions of retinoid receptors in cancer prevention and treatment
Retinoids (retinol [vitamin A] and its biologically active metabolites) are essential signaling
molecules that control various developmental pathways and influence the proliferation and …
molecules that control various developmental pathways and influence the proliferation and …
Retinoids, retinoic acid receptors, and cancer
Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
Retinoic acid signaling pathways in development and diseases
Retinoids comprise a group of compounds each composed of three basic parts: a
trimethylated cyclohexene ring that is a bulky hydrophobic group, a conjugated tetraene side …
trimethylated cyclohexene ring that is a bulky hydrophobic group, a conjugated tetraene side …
Retinoid pathway and cancer therapeutics
N Bushue, YJY Wan - Advanced drug delivery reviews, 2010 - Elsevier
The retinoids are a class of compounds that are structurally related to vitamin A. Retinoic
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …
International union of pharmacology. LXIII. Retinoid X receptors
The physiological effects of retinoic acids (RAs) are mediated by members of two families of
nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) …
nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) …
[HTML][HTML] Regulation of RXR-RAR heterodimers by RXR-and RAR-specific ligands and their combinations
A Le Maire, C Teyssier, P Balaguer, W Bourguet… - Cells, 2019 - mdpi.com
The three subtypes (α, β, and γ) of the retinoic acid receptor (RAR) are ligand-dependent
transcription factors that mediate retinoic acid signaling by forming heterodimers with the …
transcription factors that mediate retinoic acid signaling by forming heterodimers with the …