Protein aggregation is classically considered the main cause of neuronal death in
neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration …

The mammalian brain expresses several classes of noncoding RNAs (ncRNAs), including
long ncRNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs). These …

Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia
and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype …

Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

The rapid advance of RNA sequencing technologies contributed to a deep understanding of
transcriptome composition and has allowed the discovery of a large number of non-coding …

Neurodegenerative diseases constitute one of the single most important public health
challenges of the coming decades, and yet we presently have only a limited understanding …

The growing and rapid development of high-throughput sequencing technologies have
allowed a greater understanding of the mechanisms underlying gene expression regulation …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is accompanied by
deficits in memory and cognitive functions. The disease is pathologically characterised by …

The past decade has witnessed exciting breakthroughs that have contributed to the richness
and complexity of a burgeoning modern RNA world, and one particular breakthrough—the …

The emerging complexity of the transcriptional landscape poses great challenges to our
conventional preconceptions of how the genome regulates brain function and dysfunction …