Metal–Organic Framework Mediated Radio‐Enhancement Assessed in High‐Throughput‐Compatible 3D Tumor Spheroid Co‐Cultures

AL Neuer, A Vogel, A Gogos, VM Kissling… - Advanced …, 2023 - Wiley Online Library
Inorganic nanomaterials have gained increasing attention in radiation oncology, owing to
their radiation therapy enhancing properties. To accelerate candidate material selection and …

Cellular fate and performance of group IV metal organic framework radioenhancers

AL Neuer, A Jessernig, LRH Gerken, A Gogos… - Biomaterials …, 2022 - pubs.rsc.org
Nano-sized metal organic frameworks (nanoMOFs) have gained increasing importance in
biomedicine due to their tunable properties. In addition to their use as carriers in drug …

Systemic immune effects boost radiotherapy

W Ngwa - Nature biomedical engineering, 2018 - nature.com
Systemic immune effects boost radiotherapy | Nature Biomedical Engineering Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Co-delivery of PARP and PI3K inhibitors by nanoscale metal–organic frameworks for enhanced tumor chemoradiation

MJ Neufeld, AN DuRoss, MR Landry, H Winter… - Nano Research, 2019 - Springer
Due to their complementary activity, the use of DNA damage repair (DDR) inhibitors during
radiotherapy (RT) has yielded promising results. Unfortunately, this approach is often …

Interfering biosynthesis by nanoscale metal-organic frameworks for enhanced radiation therapy

Z Fu, Z Liu, J Wang, L Deng, H Wang, W Tang, D Ni - Biomaterials, 2023 - Elsevier
Radiation therapy (RT) is one of the most widely used cancer treatments. However, the
vigorous biosynthesis of cancer cells plays an important role for RT resistance. Herein, we …

High‐Z Metal–Organic Frameworks for X‐ray Radiation‐Based Cancer Theranostics

MJ Neufeld, A Lutzke, G Pratx… - Chemistry–A European …, 2021 - Wiley Online Library
X‐ray radiation is commonly employed in clinical practice for diagnostic and therapeutic
applications. Over the past decade, developments in nanotechnology have led to the use of …

Monte Carlo Simulation‐Guided Design of a Thorium‐Based Metal–Organic Framework for Efficient Radiotherapy‐Radiodynamic Therapy

Z Xu, T Luo, J Mao, C McCleary… - Angewandte Chemie …, 2022 - Wiley Online Library
High‐Z metal‐based nanoscale metal–organic frameworks (nMOFs) with photosensitizing
ligands can enhance radiation damage to tumors via a unique radiotherapy‐radiodynamic …

Multimodal Imaging-Guided Strategy for Developing 177Lu-Labeled Metal–Organic Framework Nanomedicine with Potential in Cancer Therapy

R Liang, F Li, X Chen, F Tan, T Lan… - … applied materials & …, 2023 - ACS Publications
Nano-metal–organic frameworks (nano-MOFs) labeled with radionuclides have shown great
potential in the anticancer field. In this work, we proposed to combine fluorescence imaging …

Nanoscale metal-organic frameworks for x-ray activated in situ cancer vaccination

K Ni, G Lan, N Guo, A Culbert, T Luo, T Wu… - Science …, 2020 - science.org
Cancer vaccines have been actively pursued to bolster antitumor immunity. Here, we
designed nanoscale metal-organic frameworks (nMOFs) as locally activable …

In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal–Organic Frameworks Nanomaterials

D Chen, D Yang, CA Dougherty, W Lu, H Wu, X He… - ACS …, 2017 - ACS Publications
Nanoscale metal–organic frameworks (nMOF) materials represent an attractive tool for
various biomedical applications. Due to the chemical versatility, enormous porosity, and …