Clinical benefits and pharmacology of scutellarin: a comprehensive review

L Wang, Q Ma - Pharmacology & therapeutics, 2018 - Elsevier
Stroke and myocardial infarction are among the most common causes of mortality and
disability in the world. The ischemic injury underlying these illnesses is complex, involving …

Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration

X Chen, L Cui, X Duan, B Ma, D Zhong - Drug metabolism and disposition, 2006 - ASPET
Scutellarin is widely used in treating various cardiovascular diseases. Few data are
available regarding its metabolism and pharmacokinetics in humans. The objectives of this …

Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation

J Mo, R Yang, F Li, X Zhang, B He, Y Zhang, P Chen… - Phytomedicine, 2018 - Elsevier
Background Scutellarin is the major constituent responsible for the clinical benefits of
Erigeron breviscapus (Vant.) Hand.-Mazz which finds a long history of …

Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia–reperfusion in rats

H Tang, Y Tang, N Li, Q Shi, J Guo, E Shang… - Pharmacology …, 2014 - Elsevier
Scutellarin had protective effects against neuronal injury, however, there are few studies on
the protective effect of scutellarein, which is the main metabolite of scutellarin in vivo. This …

Scutellaria baicalensis in stroke management: Nature's blessing in traditional Eastern medicine

BP Gaire, SK Moon, H Kim - Chinese journal of integrative medicine, 2014 - Springer
Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastern
medicine, especially in Chinese medicine. The major phytochemicals isolated from S …

Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats

LL Lin, AJ Liu, JG Liu, XH Yu, LP Qin… - Journal of …, 2007 - journals.lww.com
Scutellarin is an active molecule existing in Erigeron breviscapus (vant.) Hand-Mazz. The
present work was designed to study the antiischemic effects of scutellarin and its mixture …

Scutellarin protects cardiomyocyte ischemia–reperfusion injury by reducing apoptosis and oxidative stress

Z Wang, J Yu, J Wu, F Qi, H Wang, Z Wang, Z Xu - Life sciences, 2016 - Elsevier
Aims Ischemic heart disease is a leading cause of death and disability worldwide. Despite
recent advances, there is no effective therapy for preventing myocardial ischemia …

Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury

Y Zhang, X Wang, X Wang, Z Xu, Z Liu, Q Ni… - Journal of …, 2006 - Elsevier
The protective effect of flavonoids extracted from Scutellaria baicalensis Georgi on cerebral
ischemia injury has been explored in experimental animals. Scutellaria flavonoid (SF) could …

Scutellaria barbata: A review on chemical constituents, pharmacological activities and clinical applications

Q Chen, K Rahman, SJ Wang, S Zhou… - Current …, 2020 - ingentaconnect.com
Scutellaria barbata has a long history of medical use in Traditional Chinese Medicine for
removing heat and toxic material, promoting blood circulation and removing blood stasis …

[HTML][HTML] Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage

S Yang, H Wang, Y Yang, R Wang, Y Wang… - Biomedicine & …, 2019 - Elsevier
Ischemic stroke is a cerebrovascular disease with high morbidity, high mortality, and high
disability, representing a serious threat to human life and health. Clinically, the extensive …