[HTML][HTML] MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests
that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic …
that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic …
5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
DNA methylation dynamics influence brain function and are altered in neurological
disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5 …
disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5 …
5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes
5-hydroxymethylcytosine (5hmC) occurs at maximal levels in postmitotic neurons, where its
accumulation is cell-specific and correlated with gene expression. Here we demonstrate that …
accumulation is cell-specific and correlated with gene expression. Here we demonstrate that …
MeCP2 regulates gene expression through recognition of H3K27me3
MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization.
Interaction between MeCP2 and methylated DNA in the regulation of gene expression is …
Interaction between MeCP2 and methylated DNA in the regulation of gene expression is …
MeCP2: structure and function
NL Adkins, PT Georgel - Biochemistry and cell biology, 2011 - cdnsciencepub.com
Despite a vast body of literature linking chromatin structure to regulation of gene expression,
the role of architectural proteins in higher order chromatin transitions required for …
the role of architectural proteins in higher order chromatin transitions required for …
MECP2, a multi-talented modulator of chromatin architecture
F Della Ragione, M Vacca, S Fioriniello… - Briefings in …, 2016 - academic.oup.com
It has been a long trip from 1992, the year of the discovery of MECP2, to the present day.
What is surprising is that some of the pivotal roles of MeCP2 were already postulated at that …
What is surprising is that some of the pivotal roles of MeCP2 were already postulated at that …
[HTML][HTML] Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state
MeCP2 is a nuclear protein with an affinity for methylated DNA that can recruit histone
deacetylases. Deficiency or excess of MeCP2 causes severe neurological problems …
deacetylases. Deficiency or excess of MeCP2 causes severe neurological problems …
Chromatin compaction by human MeCP2: assembly of novel secondary chromatin structures in the absence of DNA methylation
PT Georgel, RA Horowitz-Scherer, N Adkins… - Journal of Biological …, 2003 - ASBMB
MeCP2 is a transcriptional repressor that contains an N-terminal methylated DNA-binding
domain, a central transcription regulation domain, and a C-terminal domain of unknown …
domain, a central transcription regulation domain, and a C-terminal domain of unknown …
MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
RP Ghosh, RA Horowitz-Scherer… - … and cellular biology, 2010 - Am Soc Microbiol
Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
MeCP2: a critical regulator of chromatin in neurodevelopment and adult brain function
Methyl CpG binding protein 2 (MeCP2) was first identified as a nuclear protein with a
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …