Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse model

S Aryal, K Bonanno, B Song, DR Mani, H Keshishian… - bioRxiv, 2022 - biorxiv.org
Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We used quantitative mass-spectrometry to carry out deep and …

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model

S Aryal, K Bonanno, B Song, DR Mani, H Keshishian… - Cell Reports, 2023 - cell.com
Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …

Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder

Z Zhao, J Xu, J Chen, S Kim, M Reimers… - Molecular …, 2015 - nature.com
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental disorders with high
heritability. Clinicians have long noticed the similarities of clinic symptoms between these …

Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia

ML MacDonald, M Garver, J Newman, Z Sun… - bioRxiv, 2019 - biorxiv.org
Importance Findings from unbiased genetic studies have consistently implicated synaptic
protein networks in Schizophrenia (Sz), but the molecular pathology at these networks and …

Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia

M Föcking, LM Lopez, JA English, P Dicker… - Molecular …, 2015 - nature.com
The postsynaptic density (PSD) contains a complex set of proteins of known relevance to
neuropsychiatric disorders, and schizophrenia specifically. We enriched for this anatomical …

[HTML][HTML] Integrative network analysis identifies differential regulation of neuroimmune system in Schizophrenia and Bipolar disorder

A Sahu, HA Chowdhury, M Gaikwad… - Brain, behavior, & …, 2020 - Elsevier
Background Neuropsychiatric disorders such as Schizophrenia (SCZ) and Bipolar disorder
(BPD) pose a broad range of problems with different symptoms mainly characterized by …

A protein-centric view of in vitro biological model systems for schizophrenia

A Chandrasekaran, P Jensen, FA Mohamed… - Stem Cells, 2021 - academic.oup.com
Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and
cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ …

Hippocampal proteomic and metabonomic abnormalities in neurotransmission, oxidative stress, and apoptotic pathways in a chronic phencyclidine rat model

H Wesseling, EJ Want, PC Guest… - Journal of Proteome …, 2015 - ACS Publications
Schizophrenia is a neuropsychiatric disorder affecting 1% of the world's population. Due to
both a broad range of symptoms and disease heterogeneity, current therapeutic approaches …

[PDF][PDF] OmicScope: from quantitative proteomics to Systems Biology

GR de Oliveira - repositorio.unicamp.br
Schizophrenia is a complex and heterogeneous psychiatric disorder. Despite much
research having been done to increase the acknowledgment about the role of each region …

Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

X Wu, R Shukla, K Alganem, X Zhang, HM Eby… - Molecular …, 2021 - nature.com
While the pathophysiology of schizophrenia has been extensively investigated using
homogenized postmortem brain samples, few studies have examined changes in brain …