Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse model
Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We used quantitative mass-spectrometry to carry out deep and …
bipolar disorder (BP). We used quantitative mass-spectrometry to carry out deep and …
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model
Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental disorders with high
heritability. Clinicians have long noticed the similarities of clinic symptoms between these …
heritability. Clinicians have long noticed the similarities of clinic symptoms between these …
Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia
ML MacDonald, M Garver, J Newman, Z Sun… - bioRxiv, 2019 - biorxiv.org
Importance Findings from unbiased genetic studies have consistently implicated synaptic
protein networks in Schizophrenia (Sz), but the molecular pathology at these networks and …
protein networks in Schizophrenia (Sz), but the molecular pathology at these networks and …
Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia
The postsynaptic density (PSD) contains a complex set of proteins of known relevance to
neuropsychiatric disorders, and schizophrenia specifically. We enriched for this anatomical …
neuropsychiatric disorders, and schizophrenia specifically. We enriched for this anatomical …
[HTML][HTML] Integrative network analysis identifies differential regulation of neuroimmune system in Schizophrenia and Bipolar disorder
A Sahu, HA Chowdhury, M Gaikwad… - Brain, behavior, & …, 2020 - Elsevier
Background Neuropsychiatric disorders such as Schizophrenia (SCZ) and Bipolar disorder
(BPD) pose a broad range of problems with different symptoms mainly characterized by …
(BPD) pose a broad range of problems with different symptoms mainly characterized by …
A protein-centric view of in vitro biological model systems for schizophrenia
A Chandrasekaran, P Jensen, FA Mohamed… - Stem Cells, 2021 - academic.oup.com
Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and
cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ …
cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ …
Hippocampal proteomic and metabonomic abnormalities in neurotransmission, oxidative stress, and apoptotic pathways in a chronic phencyclidine rat model
H Wesseling, EJ Want, PC Guest… - Journal of Proteome …, 2015 - ACS Publications
Schizophrenia is a neuropsychiatric disorder affecting 1% of the world's population. Due to
both a broad range of symptoms and disease heterogeneity, current therapeutic approaches …
both a broad range of symptoms and disease heterogeneity, current therapeutic approaches …
[PDF][PDF] OmicScope: from quantitative proteomics to Systems Biology
GR de Oliveira - repositorio.unicamp.br
Schizophrenia is a complex and heterogeneous psychiatric disorder. Despite much
research having been done to increase the acknowledgment about the role of each region …
research having been done to increase the acknowledgment about the role of each region …
Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity
While the pathophysiology of schizophrenia has been extensively investigated using
homogenized postmortem brain samples, few studies have examined changes in brain …
homogenized postmortem brain samples, few studies have examined changes in brain …
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