The two hypotheses of the origin of cancer are the “stem cell” hypothesis and the
“Dedifferentiation” or “Re-programming” hypothesis. Cancers are derived from a single cell …

The 'cancer stem cell'hypothesis has pointed to a specific target for new cancer therapies.
The hypothesis is based on the observation that only the 'cancer stem cell'among the other …

In this Commentary, the operational definition of cancer stem cells or cancer initiating cells
includes the ability of certain cells, found in a heterogeneous mixture of cells within a tumor …

Carcinogenesis is characterized by “initiation,”“promotion,” and “progression” phases. The
“stem cell theory” and “de‐differentiation” theories are used to explain the origin of cancer …

To understand the complex origin of human cancer, one cannot ignore the adage,“Nothing
in biology makes sense except in the light of evolution”[1]. In view of the fact that current …

The processes underlying the etiology of cancer have been the fodder for several theories
for a century (for a discussion of the earliest theories, see the subsequent discussion and …

Abstract Trosko, JE and Chang, CC Role of Stem Cells and Gap Junctional Intercellular
Communication in Human Carcinogenesis. Epidemiological data, experimental animal …

Cancer has long been seen as a disease that arises from mutations and epigenetic
alterations that impair the capacity of any cell within the organism to deregulation its …

Cancer tissue contains the same cell populations as do normal adult tissues: stem cells,
proliferating transit-amplifying cells, terminally differentiated (mature cells) and dead cells …

54 SCIENTIFIC AMERICAN JULY 2006 are called cancer stem cells. But they are also quite
literally believed to have once been normal stem cells or their immature offspring that have …