Dendritic cell subsets in cancer immunity and tumor antigen sensing

A Del Prete, V Salvi, A Soriani, M Laffranchi… - Cellular & molecular …, 2023 - nature.com
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

Dendritic cells and cancer: from biology to therapeutic intervention

B Wylie, C Macri, JD Mintern, J Waithman - Cancers, 2019 - mdpi.com
Inducing effective anti-tumor immunity has become a major therapeutic strategy against
cancer. Dendritic cells (DC) are a heterogenous population of antigen presenting cells that …

Molecular mechanisms involved in dendritic cell dysfunction in cancer

M Tang, J Diao, MS Cattral - Cellular and Molecular Life Sciences, 2017 - Springer
Dendritic cells (DC) play a pivotal role in the tumor microenvironment (TME). As the primary
antigen-presenting cells in the tumor, DCs modulate anti-tumor responses by regulating the …

[HTML][HTML] Tumor-infiltrating dendritic cell states are conserved across solid human cancers

GM Gerhard, R Bill, M Messemaker, AM Klein… - Journal of Experimental …, 2021 - rupress.org
Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are
emerging as an essential antitumor component based on their ability to foster T cell …

Once upon a prime: DCs shape cancer immunity

M Zagorulya, S Spranger - Trends in cancer, 2023 - cell.com
Cytotoxic CD8+ T cells are potent killers of diseased cells, but their functional capacity is
often compromised in cancer. The quality of antitumor T cell immunity is determined during T …

Insights into dendritic cells in cancer immunotherapy: from bench to clinical applications

A Salah, H Wang, Y Li, M Ji, WB Ou, N Qi… - Frontiers in Cell and …, 2021 - frontiersin.org
Dendritic cells (DCs) are efficient antigen-presenting cells (APCs) and potent activators of
naïve T cells. Therefore, they act as a connective ring between innate and adaptive …

Dendritic cells and CD8 T cell immunity in tumor microenvironment

C Fu, A Jiang - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell
immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 …

The role of dendritic cells in cancer and anti-tumor immunity

AE Marciscano, N Anandasabapathy - Seminars in immunology, 2021 - Elsevier
Dendritic cells (DC) are key sentinels of the host immune response with an important role in
linking innate and adaptive immunity and maintaining tolerance. There is increasing …

[HTML][HTML] The role of dendritic cells in tumor microenvironments and their uses as therapeutic targets

CW Kim, KD Kim, HK Lee - BMB reports, 2021 - ncbi.nlm.nih.gov
Dendritic cells (DC), which consist of several different subsets, specialize in antigen
presentation and are critical for mediating the innate and adaptive immune responses. DC …

Tumor-altered dendritic cell function: implications for anti-tumor immunity

KM Hargadon - Frontiers in immunology, 2013 - frontiersin.org
Dendritic cells (DC) are key regulators of both innate and adaptive immunity, and the array
of immunoregulatory functions exhibited by these cells is dictated by their differentiation …