Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

AS Marchev, PA Dimitrova, AJ Burns… - Annals of the New …, 2017 - Wiley Online Library
Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

Z Chen, H Zhong, J Wei, S Lin, Z Zong, F Gong… - Arthritis research & …, 2019 - Springer
Introduction Osteoarthritis (OA) is an inflammatory disease of the joints that causes
progressive disability in the elderly. Reactive oxygen species (ROS) play an important role …

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

CJ Wruck, A Fragoulis, A Gurzynski… - Annals of the …, 2011 - ard.bmj.com
Objectives Increasing evidence suggests that oxidative stress may play a key role in joint
destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of …

Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease

N Maicas, ML Ferrándiz, R Brines, L Ibanez… - Antioxidants & redox …, 2011 - liebertpub.com
Aims: Although oxidative stress participates in the etiopathogenesis of rheumatoid arthritis,
its importance in this inflammatory disease has not been fully elucidated. In this study, we …

Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis

NM Khan, I Ahmad, TM Haqqi - Free Radical Biology and Medicine, 2018 - Elsevier
Nrf2, a redox regulated transcription factor, has recently been shown to play a role in
cartilage integrity but the mechanism remains largely unknown. Osteoarthritis (OA) is a …

Redox and NF-κB signaling in osteoarthritis

P Lepetsos, KA Papavassiliou… - Free Radical Biology and …, 2019 - Elsevier
Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

D Cai, S Yin, J Yang, Q Jiang, W Cao - Arthritis research & therapy, 2015 - Springer
Introduction Osteoarthritis (OA) is a common joint disease that can cause gradual disability
among the aging population. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key …

[HTML][HTML] ROS/oxidative stress signaling in osteoarthritis

P Lepetsos, AG Papavassiliou - … et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Role of oxidative stress in pathophysiology of rheumatoid arthritis: Insights into NRF2-KEAP1 signalling

G Kaur, A Sharma, A Bhatnagar - Autoimmunity, 2021 - Taylor & Francis
Rheumatoid arthritis is one of the most prevalent, chronic, inflammatory disorders involving
multiple articular and extra-articular complications. Immune deregulation owing to a …

Relevance of Nrf2 and heme oxygenase-1 in articular diseases

MJ Alcaraz, ML Ferrándiz - Free Radical Biology and Medicine, 2020 - Elsevier
Joint conditions pose an important public health problem as they are a leading cause of
pain, functional limitation and physical disability. Oxidative stress is related to the …