The vinca alkaloids have been used in the treatment of cancer for over 40 years. Their
efficacy has ensured that they remain among the drugs of choice for a number of human …

Tubulin is the biochemical target for several clinically used anticancer drugs, including
paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the …

Anticancer agents that interfere with microtubulin function are in widespread use in man and
have a broad spectrum of activity against both hematological malignancies and solid tumors …

Microtubule-interacting drugs are important agents in cancer chemotherapy. Some of these
drugs alter microtubule dynamics and engage the cell cycle surveillance mechanisms to …

Most investigators would agree that the ideal chemotherapeutic agent should be 1) directed
at a validated target; 2) potent, preferably active at nanomolar or subnanomolar …

Microtubules, major structural components in cells, are the target of a large and diverse
group of natural product anticancer drugs. Given the success of this class of drugs in cancer …

Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and
biophysical properties have made α-and β-tubulin, the main components of MTs, the subject …

We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit
cell proliferation primarily by means of their effects on mitotic spindle microtubules or by …

Highly dynamic mitotic-spindle microtubules are among the most successful targets for
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …

Background: Many critical cellular functions such as mitosis, cell movement, and
maintenance of cell structure are performed by microtubules. Antimicrotubule agents (which …