Cancer cells evolve in the tumor microenvironment (TME) by the acquisition of
characteristics that allow them to initiate their passage through a series of events that …

The microenvironment or stroma immediately surrounding tumor cells consists of a three‐
dimensional extracellular matrix (ECM) and stromal cells such as fibroblasts and …

Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly
influenced by the surrounding microenvironment of the tumor. Therefore, the ability to …

The increasing diversity in both substrates and functions of matrix metalloproteinases
(MMPs) makes these enzymes central regulators in the complex tumor ecosystem …

Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

The extracellular matrix (ECM) provides a physical framework for the cells and functions as a
gel medium. Remodeling of the ECM is crucial during physiological cell migration …

Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to
unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis …

The malignant progression of tumors is driven by the expression of oncogenes and loss of
expression of tumor suppressor genes; factors that are intrinsic to cancer cells. The …

[Frontiers in Bioscience 11, 479-491, January 1, 2006] 479 Matrix metalloproteinases: roles in
cancer and metastasis Barbara Fin Page 1 [Frontiers in Bioscience 11, 479-491, January 1 …

Matrix metalloproteinases (MMPs) are a family of more than 28 enzymes that were initially
identified on the basis of their ability to cleave most elements of the extracellular matrix …