A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage
Malaria infection involves an obligatory, yet clinically silent liver stage,. Hepatocytes operate
in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along …
in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along …
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle
INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …
organisms with distinct morphological developmental stages each specialized to inhabit …
Quantitative imaging of Plasmodium transmission from mosquito to mammal
Plasmodium, the parasite that causes malaria, is transmitted by a mosquito into the dermis
and must reach the liver before infecting erythrocytes and causing disease. We present here …
and must reach the liver before infecting erythrocytes and causing disease. We present here …
Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events
Background Plasmodium sporozoites migrate to the liver where they traverse several
hepatocytes before invading the one inside which they will develop and multiply into …
hepatocytes before invading the one inside which they will develop and multiply into …
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites
Single-cell RNA-sequencing is revolutionising our understanding of seemingly
homogeneous cell populations but has not yet been widely applied to single-celled …
homogeneous cell populations but has not yet been widely applied to single-celled …
RNA-Seq Analysis Illuminates the Early Stages of Plasmodium Liver Infection
M Toro-Moreno, K Sylvester, T Srivastava, D Posfai… - MBio, 2020 - Am Soc Microbiol
The apicomplexan parasites Plasmodium spp. are the causative agents of malaria, a
disease that poses a significant global health burden. Plasmodium spp. initiate infection of …
disease that poses a significant global health burden. Plasmodium spp. initiate infection of …
Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development
Background The complex life cycle of malaria parasites requires well-orchestrated stage
specific gene expression. In the vertebrate host the parasites grow and multiply by …
specific gene expression. In the vertebrate host the parasites grow and multiply by …
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution
GG Rutledge, U Böhme, M Sanders, AJ Reid… - Nature, 2017 - nature.com
Elucidation of the evolutionary history and interrelatedness of Plasmodium species that
infect humans has been hampered by a lack of genetic information for three human-infective …
infect humans has been hampered by a lack of genetic information for three human-infective …
The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species
A Kaushansky, SHI Kappe - Nature medicine, 2011 - nature.com
Protozoan parasites of the genus Plasmodiumare the vector-borne causative agents of
malaria, responsible for more than 350 million clinical cases and one million deaths …
malaria, responsible for more than 350 million clinical cases and one million deaths …
Migration through host cells activates Plasmodium sporozoites for infection
MM Mota, JCR Hafalla, A Rodriguez - Nature medicine, 2002 - nature.com
Plasmodium sporozoites, the infective stage of the malaria parasite transmitted by
mosquitoes, migrate through several hepatocytes before infecting a final one. Migration …
mosquitoes, migrate through several hepatocytes before infecting a final one. Migration …