Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Anticonvulsant mechanisms of the ketogenic diet

KJ Bough, JM Rho - Epilepsia, 2007 - Wiley Online Library
The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy.
Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain …

How does the ketogenic diet induce anti-seizure effects?

JM Rho - Neuroscience letters, 2017 - Elsevier
The high-fat ketogenic diet (KD) is a remarkably effective treatment for medically intractable
epilepsy and has been part of the clinical armamentarium for nearly a century. However, the …

New insights into the mechanisms of the ketogenic diet

D Boison - Current opinion in neurology, 2017 - journals.lww.com
New insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology New
insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology Log in or …

Therapeutic use of the ketogenic diet in refractory epilepsy: what we know and what still needs to be learned

IM Zarnowska - Nutrients, 2020 - mdpi.com
Ketogenic diet (KD) has been used to treat epilepsy for 100 years. It is a high-fat, low-
carbohydrate, and sufficient-protein-for-growth diet that mimics the metabolic changes …

[PDF][PDF] The ketogenic diet: from molecular mechanisms to clinical effects

J Freeman, P Veggiotti, G Lanzi, A Tagliabue… - Epilepsy Res, 2006 - academia.edu
Recent years have witnessed an increased interest from pediatric neurologists,
neuropediatricians, epileptologists and general neurologists in the use of the ketogenic diet …

[HTML][HTML] Mechanisms of ketogenic diet action

SA Masino, JM Rho - Jasper's Basic Mechanisms of the Epilepsies …, 2012 - ncbi.nlm.nih.gov
Within the past two decades, interest in understanding the therapeutic mechanisms of
ketogenic diet (KD) action has grown steadily. Expanded knowledge about underlying …

[HTML][HTML] The mechanisms mediating the antiepileptic effects of the ketogenic diet, and potential opportunities for improvement with metabolism-altering drugs

NA Youngson, MJ Morris, JWO Ballard - Seizure, 2017 - Elsevier
The ketogenic diet (KD) is increasingly being used to treat patients with intractable epilepsy.
Despite decades of research, the reason for its success, when anticonvulsants have failed …

The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy

DN Ruskin, SA Masino - Frontiers in neuroscience, 2012 - frontiersin.org
A link between metabolism and brain function is clear. Since ancient times, epileptic
seizures were noted as treatable with fasting, and historical observations of the therapeutic …

Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?

TA Simeone, KA Simeone, CE Stafstrom, JM Rho - Neuropharmacology, 2018 - Elsevier
Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet
(KD) remain unclear, a long-standing question has been whether ketone bodies (ie, β …