Objectives: Decellularized extracellular matrix (dECM) is increasingly used in a wide range
of regenerative medicine applications and may also offer the potential to support injured …

Decellularized extracellular matrix (dECM) derived from myocardium has been widely
explored as a nature scaffold for cardiac tissue engineering applications. Cardiac dECM …

Introduction. Selection of a biomaterial-based scaffold that mimics native myocardial
extracellular matrix (ECM) architecture can facilitate functional cell attachment and …

Engineering microenvironments for accelerated myocardial repair is a challenging goal. Cell
therapy has evolved over a few decades to engraft therapeutic cells to replenish lost …

BACKGROUND: Maladaptive remodeling following acute ischemic injury is driven by
persistent cardiac fibroblast activation and extracellular matrix (ECM) dysregulation …

Structural cardiac remodeling after ischemic injury can induce a transition to heart failure
from progressive loss of cardiac function. Cellular regenerative therapies are promising but …

Acellular cardiac patches made of various biomaterials have shown to improve heart
function after myocardial infarction (MI). Extracellular matrix scaffold derived from a …

Despite the advent of tissue engineering (TE) for the remodeling, restoring, and replacing
damaged cardiovascular tissues, the progress is hindered by the optimal mechanical and …

Injectable biomaterials have been developed as potential minimally invasive therapies for
treating myocardial infarction (MI) and heart failure. Christman et al. first showed that the …

Heart disease remains a leading killer in western society and irreversibly impacts the lives of
millions of patients annually. While adult mammals do not possess the ability to regenerate …