Intermittent fasting (IF) is gaining popularity for its effectiveness in improving overall health,
including its effectiveness in achieving weight loss and euglycemia. The molecular …

The NAD+‐dependent SIRT6 deacetylase is a therapeutic candidate against the emerging
metabolic syndrome epidemic. SIRT6, whose deficiency in mice results in premature aging …

Objective: Calorie restriction increases the life span in a number of different organisms. This
effect is dependent upon activation of the Sirt1 enzyme, and many of the beneficial effects of …

Brown adipose tissue plays a central role in the regulation of the energy balance by
expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been …

Adipose tissue inflammation is a reproducible feature of obesity and obesity-linked insulin
resistance. Although sirtuin 6 (Sirt6) deficiency has previously been implicated in diet …

Sirt6 is an NAD+-dependent deacetylase that is involved in the control of energy
metabolism. However, the tissue-specific function of Sirt6 in the adipose tissue remains …

Abstract Mammalian sirtuin 6 (SIRT6) is involved in the regulation of many essential
processes, especially metabolic homeostasis. SIRT6 knockout mice undergo premature …

Objective Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal.
Thus, identifying novel molecular target (s) exerting protective effects against these …

Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase
and ADP-ribose transferase enzyme. It has an important role in physiological and …

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to
delay age-related physiological decline in mammalian organisms. SIRT1, a NAD+ …