Autoimmune myocarditis is the limited or diffuse inflammation of the myocardium due to
dysfunctional cellular and humoral immunity mechanisms. We constructed mouse models of …

Myocarditis is a major cause of sudden, unexpected death in young people. However, it is
still one of the most challenging diseases to treat in cardiology. In the present study, we …

Aims Myocarditis is associated with formidable symptoms and increased risk of adverse
outcomes. Current approaches mostly rely on symptomatic treatments, warranting novel …

Acute myocarditis is a clinically serious disease; however, no effective treatment has been
elucidated. Cyclooxygenase (COX)-2 is a key factor for progression of inflammation …

Myocarditis is an inflammatory disease of the heart and a major cause of dilated
cardiomyopathy that can lead to heart failure and sudden death in young adults. Giant cell …

Backgrounds Autoimmune myocarditis is characterized by over-activated immune system
attacking the cardiomyocytes, resulting in heart function decline. In the current study, we …

Backgroud Macrophages are important mediators in inflammatory cardiovascular diseases.
Experimental autoimmune myocarditis (EAM) is characterized by pronounced macrophages …

Autoimmune responses and inflammation are involved in the pathogenesis of many
cardiovascular diseases. There is compelling evidence that inflammatory mechanisms may …

Objective To investigate the therapeutic effect of IL-6 mAb on experimental autoimmune
myocarditis (EAM) in rats, and search the mechanism of the role of IL-6, helper T cells 17 …

Methods BALB/c mice were randomly divided into three groups, AS605240 group and
vehicle group were injected subcutaneously with emulsions containing CFA and 100 ng …