Introduction The current therapeutic armamentarium to prevent chronic kidney disease
(CKD) progression is limited to the control of blood pressure and in diabetic patients, the …

Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …

Introduction Diabetic kidney disease (DKD) is the most common cause of end-stage renal
disease (ESRD) worldwide. Currently, there is no effective treatment to completely prevent …

Renal fibrosis is a common irreversible process of chronic kidney disease (CKD)
characterized by uncontrolled deposits of extracellular matrix, replacement of cellular …

Many types of kidney injury induce inflammation as a protective response. However,
unresolved inflammation promotes progressive renal fibrosis, which can culminate in end …

Renal inflammation is the initial, healthy response to renal injury. However, prolonged
inflammation promotes the fibrosis process, which leads to chronic pathology and eventually …

Chronic kidney disease (CKD) is a major health and economic burden with a rising
incidence. During progression of CKD, the sustained release of proinflammatory and …

The incidence of chronic kidney diseases (CKDs) is expected to rise, fuelled by the ever
increasing epidemic of Type 2 diabetes. Despite extensive research in this area, there are …

Renal fibrosis is the culmination of processes driven by signaling pathways involving
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …

Elevated expression of the multifunctional cytokine transforming growth factor β1 (TGF-β1) is
causatively linked to kidney fibrosis progression initiated by diabetic, hypertensive …