Germline risk of clonal haematopoiesis
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …
somatic mutations that is associated with an increased risk of haematological malignancies …
Clonal hematopoiesis and its impact on human health
Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
Clonal hematopoiesis and risk for hematologic malignancy
JT Warren, DC Link - Blood, The Journal of the American …, 2020 - ashpublications.org
Clonal hematopoiesis (CH) is common in older persons and is associated with an increased
risk of hematologic cancer. Here, we review studies establishing an association between CH …
risk of hematologic cancer. Here, we review studies establishing an association between CH …
Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals
IA van Zeventer, AO de Graaf… - Blood, The Journal …, 2020 - ashpublications.org
Anemia is a major and currently poorly understood clinical manifestation of hematopoietic
aging. Upon aging, hematopoietic clones harboring acquired leukemia-associated …
aging. Upon aging, hematopoietic clones harboring acquired leukemia-associated …
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
F Zink, SN Stacey, GL Norddahl… - Blood, The Journal …, 2017 - ashpublications.org
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis
SP Kar, PM Quiros, M Gu, T Jiang, J Mitchell… - Nature Genetics, 2022 - nature.com
Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
Stably acquired mutations in hematopoietic cells represent substrates of selection that may
lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with …
lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with …
Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged≥ 80 years
IA van Zeventer, JB Salzbrunn, AO de Graaf… - Blood …, 2021 - ashpublications.org
Clonal hematopoiesis (CH), characterized by a fraction of peripheral blood cells carrying an
acquired genetic variant, emerges with age. Although in general CH is associated with …
acquired genetic variant, emerges with age. Although in general CH is associated with …
Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation
Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid
malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting …
malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting …
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …