Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

Clonal hematopoiesis (CH) is common in older persons and is associated with an increased
risk of hematologic cancer. Here, we review studies establishing an association between CH …

Anemia is a major and currently poorly understood clinical manifestation of hematopoietic
aging. Upon aging, hematopoietic clones harboring acquired leukemia-associated …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

Stably acquired mutations in hematopoietic cells represent substrates of selection that may
lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with …

Clonal hematopoiesis (CH), characterized by a fraction of peripheral blood cells carrying an
acquired genetic variant, emerges with age. Although in general CH is associated with …

Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid
malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …