[HTML][HTML] Restoring nervous system structure and function using tissue engineered living scaffolds

LA Struzyna, JP Harris, KS Katiyar… - Neural regeneration …, 2015 - journals.lww.com
Neural tissue engineering is premised on the integration of engineered living tissue with the
host nervous system to directly restore lost function or to augment regenerative capacity …

Neural tissue engineering for neuroregeneration and biohybridized interface microsystems in vivo (Part 2)

DK Cullen, JA Wolf, DH Smith… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Neural tissue engineering offers tremendous promise to combat the effects of disease,
aging, or injury in the nervous system. Here we review neural tissue engineering with …

Living scaffolds for neuroregeneration

LA Struzyna, K Katiyar, DK Cullen - Current Opinion in Solid State and …, 2014 - Elsevier
Neural tissue engineers are exploiting key mechanisms responsible for neural cell migration
and axonal pathfinding during embryonic development to create living scaffolds for …

Tissue-engineering approaches for axonal guidance

N Zhang, H Yan, X Wen - Brain Research Reviews, 2005 - Elsevier
Owing to the profound impact of nervous system damage, extensive studies have been
carried out aimed at facilitating axonal regeneration following injury. Tissue engineering, as …

Neural tissue engineering: From bioactive scaffolds and in situ monitoring to regeneration

B Gong, X Zhang, AA Zahrani, W Gao, G Ma… - …, 2022 - Wiley Online Library
Peripheral nerve injury is a large‐scale problem that annually affects more than several
millions of people all over the world. It remains a great challenge to effectively repair nerve …

[HTML][HTML] Bundled three-dimensional human axon tracts derived from brain organoids

DK Cullen, WJ Gordián-Vélez, LA Struzyna… - Iscience, 2019 - cell.com
Reestablishing cerebral connectivity is a critical part of restoring neuronal network integrity
and brain function after trauma, stroke, and neurodegenerative diseases. Creating …

[HTML][HTML] Scaffolds with anisotropic structure for neural tissue engineering

Y Hu, H Zhang, H Wei, H Cheng, J Cai, X Chen… - Engineered …, 2022 - Elsevier
Nervous system injuries remain a great challenge due to limited natural tissue regeneration
capabilities. Neural tissue engineering has been regarded as a promising approach for …

Microtissue engineered constructs with living axons for targeted nervous system reconstruction

DK Cullen, MD Tang-Schomer, LA Struzyna… - … Engineering Part A, 2012 - liebertpub.com
As a common feature of many neurological diseases and injury, the loss of axon pathways
can have devastating effects on function. Here, we demonstrate a new strategy to restore …

[HTML][HTML] Anatomically inspired three-dimensional micro-tissue engineered neural networks for nervous system reconstruction, modulation, and modeling

LA Struzyna, DO Adewole… - Journal of Visualized …, 2017 - ncbi.nlm.nih.gov
Functional recovery rarely occurs following injury or disease-induced degeneration within
the central nervous system (CNS) due to the inhibitory environment and the limited capacity …

Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration

CC Winter, KS Katiyar, NS Hernandez, YJ Song… - Acta biomaterialia, 2016 - Elsevier
Neurotrauma, stroke, and neurodegenerative disease may result in widespread loss of
neural cells as well as the complex interconnectivity necessary for proper central nervous …