[HTML][HTML] Advancements in assessments of bio-tissue engineering and viable cell delivery matrices using bile acid-based pharmacological biotechnologies

A Mooranian, M Jones, CM Ionescu, D Walker… - Nanomaterials, 2021 - mdpi.com
The utilisation of bioartificial organs is of significant interest to many due to their versatility in
treating a wide range of disorders. Microencapsulation has a potentially significant role in …

Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem

A Mooranian, M Jones, CM Ionescu, D Walker… - Therapeutic …, 2021 - Future Science
Microencapsulation of formulation designs further expands the field and offers the potential
for use in developing bioartificial organs via cell encapsulation. Combining formulation …

The emerging role of bile acids as critical components in nanotechnology and bioengineering: Pharmacology, formulation optimizers and hydrogel-biomaterial …

B Kovacevic, M Jones, C Ionescu, D Walker, S Wagle… - Biomaterials, 2022 - Elsevier
The role of endogenous bile acids as lipid stabilizers aiding uptake of lipophilic nutrients via
micelle formation and saponification effects is well documented and precedes their growing …

Biological assessments of encapsulated pancreatic β-cells: their potential transplantation in diabetes

A Mooranian, R Negrulj, E Jamieson… - Cellular and Molecular …, 2016 - Springer
Microencapsulation of pancreatic islets has been considered as a promising method for cell
transplantation and diabetes treatment. However, in vivo trials to date have been hampered …

Objectively assessing bioartificial organs

D Hunkeler, A Rehor, I Ceausoglu… - Annals of the New …, 2001 - Wiley Online Library
The metrics used, thus far, to assess bioartificial organ function are shown to be subjective
and requiring validation. Therefore, four categories of correlations are proposed based on …

[HTML][HTML] Progress and current limitations of materials for artificial bile duct engineering

Q Sun, Z Shen, X Liang, Y He, D Kong, AC Midgley… - Materials, 2021 - mdpi.com
Bile duct injury (BDI) and bile tract diseases are regarded as prominent challenges in
hepatobiliary surgery due to the risk of severe complications. Hepatobiliary, pancreatic, and …

[HTML][HTML] Pharmacological dose-effect profiles of various concentrations of humanised primary bile acid in encapsulated cells

A Mooranian, M Jones, D Walker, CM Ionescu… - Nanomaterials, 2022 - mdpi.com
Bile acids (BA) s are known surfactants and well-documented to play a major role in food
digestion and absorption. Recently, potential endocrinological and formulation-stabilisation …

[HTML][HTML] Artificial cell encapsulation for biomaterials and tissue bio-nanoengineering: history, achievements, limitations, and future work for potential clinical …

A Mooranian, M Jones, CM Ionescu, D Walker… - Journal of Functional …, 2021 - mdpi.com
Pancreatic β-cell loss and failure with subsequent deficiency of insulin production is the
hallmark of type 1 diabetes (T1D) and late-stage type 2 diabetes (T2D). Despite the …

Long-term biocompatibility, chemistry, and function of microencapsulated pancreatic islets

P de Vos, CG van Hoogmoed, J van Zanten, S Netter… - Biomaterials, 2003 - Elsevier
Transplantation of encapsulated living cells is a promising approach for the treatment of a
wide variety of diseases. Large-scale application of the technique, however, is hampered by …

Characterization of a novel bile acid-based delivery platform for microencapsulated pancreatic β-cells

A Mooranian, R Negrulj, F Arfuso… - Artificial cells …, 2016 - Taylor & Francis
Introduction In a recent study, we confirmed good chemical and physical compatibility of
microencapsulated pancreatic β-cells using a novel formulation of low viscosity sodium …