Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

C Jin, Y Luo, Z Liang, X Li, D Kołat, L Zhao… - Journal of Translational …, 2023 - Springer
The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling

L Fu, K Shi, J Wang, W Chen, D Shi, Y Tian, W Guo… - Molecular Cancer, 2014 - Springer
Background TFAP2B is a member of the AP2 transcription factor family, which orchestrates a
variety of cell processes. However, the roles of TFAP2B in regulating carcinogenesis remain …

An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity

JN Liu, XS Kong, P Sun, R Wang, W Li… - Journal of Cellular and …, 2021 - Wiley Online Library
Studies have shown that transcription factor activating enhancer binding protein 4 (TFAP4)
plays a vital role in multiple types of cancer; however, the TFAP4 expression profile is still …

[HTML][HTML] TFAP2A promotes cervical cancer via a positive feedback pathway with PD‑L1

J Yang, Y Gao, S Yao, S Wan… - Oncology reports, 2023 - spandidos-publications.com
Transcription factor AP‑2 alpha (TFAP2A) is a critical cell growth regulator that is
overexpressed in various tumor tissues. However, its role in the development of cervical …

TFAP4 promotes hepatocellular carcinoma invasion and metastasis via activating the PI3K/AKT signaling pathway

T Huang, QF Chen, BY Chang, LJ Shen, W Li… - Disease …, 2019 - Wiley Online Library
Transcription factor activating enhancer binding protein 4 (TFAP4) is established as a
regulator of human cancer genesis and progression. Overexpression of TFAP4 indicates …

TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial–mesenchymal transition

W Kim, EG Kim, S Lee, D Kim, J Chun… - … & molecular medicine, 2016 - nature.com
TFAP2C (transcription factor-activating enhancer-binding protein 2C) expression has been
positively correlated with poor prognosis in patients with certain types of cancer, but the …

TFAP4 promotes the growth of prostate cancer cells by upregulating FOXK1

Y Gu, J Jiang, C Liang - Experimental and Therapeutic …, 2021 - spandidos-publications.com
Transcription factor activating enhancer binding protein 4 (TFAP4) has been indicated to be
correlated with the progression of various human malignancies. However, the effect and …

[HTML][HTML] Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma

J Song, C Xie, L Jiang, G Wu, J Zhu, S Zhang… - Theranostics, 2018 - ncbi.nlm.nih.gov
It has been reported that the transcription factor activating enhancer-binding protein 4
(TFAP4) is upregulated and associated with an aggressive phenotype in several cancers …

TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway

X Fu, H Zhang, Z Chen, Z Yang, D Shi, T Liu… - Cell death & …, 2019 - nature.com
Thyroid cancer is commonly seen in the clinic with a rapidly increasing incidence globally.
COX-2 overexpression correlates with the pathologic type of thyroid carcinoma, and it has …

TFAP2C promotes stemness and chemotherapeutic resistance in colorectal cancer via inactivating hippo signaling pathway

X Wang, D Sun, J Tai, S Chen, M Yu, D Ren… - Journal of Experimental & …, 2018 - Springer
Background Aberrant expression of transcription Factor AP-2 Gamma (TFAP2C) has been
reported to be implicated in malignant process of many cancers. The purpose of this study is …