[HTML][HTML] A human lung alveolus-on-a-chip model of acute radiation-induced lung injury

Q Dasgupta, A Jiang, AM Wen, RJ Mannix… - Nature …, 2023 - nature.com
Acute exposure to high-dose gamma radiation due to radiological disasters or cancer
radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute …

[HTML][HTML] An interactive murine single-cell atlas of the lung responses to radiation injury

S Curras-Alonso, J Soulier, T Defard, C Weber… - Nature …, 2023 - nature.com
Abstract Radiation Induced Lung Injury (RILI) is one of the main limiting factors of thorax
irradiation, which can induce acute pneumonitis as well as pulmonary fibrosis, the latter …

[HTML][HTML] The cellular and molecular mechanism of radiation-induced lung injury

Y Huang, W Zhang, F Yu, F Gao - Medical science monitor …, 2017 - ncbi.nlm.nih.gov
The lung is one of several moderately radiosensitive organs. Radiation-induced lung injury
(RILI), including acute radiation pneumonitis and chronic radiation-induced pulmonary …

Radiation-induced lung injury: assessment and management

AN Hanania, W Mainwaring, YT Ghebre, NA Hanania… - Chest, 2019 - Elsevier
Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation
therapy (RT) and manifests acutely as radiation pneumonitis and chronically as radiation …

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis

P Rubin, CJ Johnston, JP Williams, S McDonald… - International Journal of …, 1995 - Elsevier
Purpose: Radiation-induced pulmonary reactions have classically been viewed as distinct
phases-acute pneumonitis and, later, fibrosis-occurring at different times after irradiation and …

Inflammatory cell recruitment following thoracic irradiation

CJ Johnston, JP Williams, A Elder… - Experimental lung …, 2004 - Taylor & Francis
Ionizing radiation leads to a progressive injury in which a monocyte/macrophage-rich
pneumonitis is followed by a chronic progressive fibrosis. In the present study, the role of …

Radiation damage to the lung: Mitigation by angiotensin‐converting enzyme (ACE) inhibitors

M Medhora, F Gao, ER Jacobs, JE Moulder - Respirology, 2012 - Wiley Online Library
Concern regarding accidental overexposure to radiation has been raised after the
devastating Tohuku earthquake and tsunami which initiated the Fukushima Daiichi nuclear …

Biology of radiation-induced lung injury

S Roy, KE Salerno, DE Citrin - Seminars in radiation oncology, 2021 - Elsevier
Radiation-induced lung injury encompasses radiation-induced pneumonitis, inflammation of
the lung which may manifest as a dose-limiting acute or subacute toxicity, and radiation …

[HTML][HTML] The role of alveolar epithelium in radiation-induced lung injury

C Almeida, D Nagarajan, J Tian, SW Leal, K Wheeler… - PloS one, 2013 - journals.plos.org
Pneumonitis and fibrosis are major lung complications of irradiating thoracic malignancies.
In the current study, we determined the effect of thoracic irradiation on the lungs of FVB/N …

Radiation pulmonary toxicity: from mechanisms to management

PR Graves, F Siddiqui, MS Anscher… - Seminars in radiation …, 2010 - Elsevier
The goal of radiation therapy is to reduce or eliminate tumor burden while sparing normal
tissues from long-term injury. Thoracic radiation presents a unique challenge because of the …