The MET gene, known as MET proto-oncogene receptor tyrosine kinase, was first identified
to induce tumor cell migration, invasion, and proliferation/survival through canonical RAS …

The c-MET proto-oncogene (MET) plays an important role in lung oncogenesis, affecting
cancer-cell survival, growth and invasiveness. The MET receptor in non-small–cell lung …

Targeting the MET pathway in advanced NSCLC has been of particular interest due to its
role as both a primary oncogenic driver and secondary oncogenic driver of acquired …

Introduction: The MET gene and its pathway normally plays a crucial role in cell
homeostasis, motility, and apoptosis. However, when the MET gene is altered, there is an …

Recently, a better understanding of the specific mechanisms of oncogene addiction has led
to the development of antitumor strategies aimed at blocking these abnormalities in different …

The Met receptor tyrosine kinase (RTK) is an attractive oncology therapeutic target. Met and
its ligand, HGF, play a central role in signaling pathways that are exploited during the …

Several molecular abnormalities in the MET gene have been identified, including
overexpression, amplification, point mutations, and “skipping mutation” in exon 14. Even …

Conclusion There are different options to inhibit Met activation and these are in part limited
depending on the transforming phenotype. For example, inhibiting ligand/receptor …

Although targeted therapies have increased the life expectancy of patients with druggable
molecular alterations directly involved in tumor development, the efficacy of these therapies …

Therapies targeting receptor tyrosine kinases have shown efficacy in molecularly defined
subsets of cancers. Unfortunately, cancers invariably develop resistance, and overcoming or …