Blockage of the renin-angiotensin system (RAS) is now recognized as an effective approach
to the treatment of hypertension and congestive heart failure. Today, it is possible to …

The renin-angiotensin system (RAS) plays an important role in regulating blood pressure,
and maintaining fluid and electrolyte balance. Angiotensin II is the principal mediator of the …

Abstract Angiotensin II (AT-II)-receptor antagonists are reviewed. Research focused on
blocking the renin-angiotensin system (RAS) led to the discovery of angiotensin-converting …

The renin–angiotensin system is integral to the mechanisms that regulate cardiovascular
homeostasis. The renin–angiotensin system has an important role in the pathophysiology of …

Angiotensin II receptor blockers represent a class of effective and well tolerated orally active
antihypertensive drugs. Activation of AT 1 receptors leads to vasoconstriction, stimulation of …

Angiotensin II receptor antagonists (AAIIs) are the most specific inhibitors of the renin-
angiotensin-aldosterone system. There are two types of angiotensin II (Ang II) receptors, the …

In the near future orally active, selective and specific type 1 angiotensin II (AT) receptor
antagonists will be available for clinical use in hypertension and in left ventricular …

Acceptance of the notion that physiologically specific interruption of the renin-angiotensin-
aldosterone system (RAAS) is of considerable therapeutic benefit in the treatment of …

Blockade of the renin-angiotensin system by angiotensin converting enzyme (ACE)
inhibitors has an established role in the management of hypertension, heart failure, patients …

The introduction of Angiotensin II receptor blockers (ARB) in 1995 was another milestone in
the pharmacological management of hypertension. Due to the manifold effects on several …