Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of
embryonic stem cells (ESCs). We show that telomere-associated protein Rif1 is required to …

Telomere length maintenance ensures self-renewal of human embryonic stem cells (hESCs)
and induced pluripotent stem cells (hiPSCs); however, the mechanisms governing telomere …

Functional telomeres are critical for stem cell proliferation; however, whether they are
equally important for the stability of stem cell differentiation is not known. We found that …

Proper telomere length is essential for embryonic stem cell (ESC) self-renewal and
pluripotency. Mouse ESCs (mESCs) sporadically convert to a transient totipotent state …

Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve
genomic stability. However, the molecular mechanisms underlying telomere attrition …

Embryonic stem cells (ESCs), somatic cell nuclear transfer ESCs, and induced pluripotent
stem cells (iPSCs) represent the most studied group of PSCs. Unlimited self-renewal without …

Telomeres are distinctive structures that protect the ends of linear chromosomes and ensure
genome stability. They are composed of long tracks of repetitive and G-rich DNA that is …

Proper telomere length is essential for indefinite self-renewal of embryonic stem (ES) cells
and cancer cells. Telomerase-deficient late generation mouse ES cells and human ALT …

Little is known about the telomere chromatin dynamics of embryonic stem (ES) cell. Here, we
demonstrate localization of histone H3. 3 at interphase telomeres and enrichment of Ser31 …

Telomeres play vital roles in ensuring chromosome stability and are thus closely linked with
the onset of aging and human disease. Telomeres undergo extensive lengthening during …