Glucokinase (GK) is highly expressed in the hypothalamic paraventricular nucleus (PVN);
however, its role is currently unknown. We found that GK in the PVN acts as part of a glucose …

The peptide hormone glucagon-like peptide-1 (GLP-1) enhances glucose-induced insulin
secretion and inhibits both gastric emptying and glucagon secretion. GLP-1 receptor (GLP …

Glucose homeostasis is performed by specialized cells types that detect and respond to
changes in systemic glucose concentration. Hepatocytes, β-cells and hypothalamic …

Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining
energy homeostasis. Glucagon-like peptide-1 (GLP-1, encoded by Gcg), secreted by a …

Objective Glucagon-like peptides are co-released from enteroendocrine L cells in the gut
and preproglucagon (PPG) neurons in the brainstem. PPG-derived GLP-1/2 are probably …

It has recently been proposed that hypothalamic glial cells sense glucose levels and release
lactate as a signal to activate adjacent neurons. GK (glucokinase), the hexokinase involved …

Glucagon-like peptide-1 (GLP-1) regulates energy homeostasis via activation of the GLP-1
receptors (GLP-1Rs) in the central nervous system. However, the mechanism by which the …

Summary Glucagon-like peptides (GLP-1/GLP-2) are coproduced and highlighted as key
modulators to improve glucose homeostasis and insulin sensitivity after bariatric surgery …

The brain relies on a constant supply of glucose, its primary fuel, for optimal function. A taste-
independent mechanism within the CNS that promotes glucose delivery to the brain has …

The paraventricular nucleus of the thalamus (PVT) controls goal-oriented behavior through
its connections to the nucleus accumbens (NAc). We previously characterized Glut2 aPVT …