Placental function in maternal obesity

AC Kelly, TL Powell, T Jansson - Clinical Science, 2020 - portlandpress.com
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

[HTML][HTML] Effects of maternal obesity on placental function and fetal development

KR Howell, TL Powell - Reproduction (Cambridge, England), 2017 - ncbi.nlm.nih.gov
Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …

Maternal pre-pregnancy obesity is associated with altered placental transcriptome

S Altmäe, MT Segura, FJ Esteban, S Bartel, P Brandi… - PloS one, 2017 - journals.plos.org
Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence
that maternal obesity has a negative influence on placental development and function …

Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth

FJ Rosario, TL Powell… - American Journal of …, 2016 - journals.physiology.org
Fetal overgrowth is common in obese women and is associated with perinatal complications
and increased risk for the child to develop metabolic syndrome later in life. Placental nutrient …

Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes

J Martino, S Sebert, MT Segura… - The Journal of …, 2016 - academic.oup.com
Context: Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to
adverse neonatal outcomes. The extent to which this may be mediated by differences in …

Obesity and the placenta: a consideration of nutrient exchange mechanisms in relation to aberrant fetal growth

L Higgins, SL Greenwood, M Wareing, CP Sibley… - Placenta, 2011 - Elsevier
The obesity epidemic, including childhood obesity, is rapidly gaining strength as one of the
most significant challenges to the health of the global community in the 21st Century. The …

Maternal obesity: new placental paradigms unfolded

C Brombach, W Tong, DA Giussani - Trends in molecular medicine, 2022 - cell.com
The prevalence of maternal obesity is increasing at an alarming rate, and is providing a
major challenge for obstetric practice. Adverse effects on maternal and fetal health are …

Maternal obesity, metabolism, and pregnancy outcomes

JC King - Annu. Rev. Nutr., 2006 - annualreviews.org
▪ Abstract About one third of all pregnant women in the United States are obese. Maternal
obesity at conception alters gestational metabolic adjustments and affects placental …

Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions

L Huang, J Liu, L Feng, Y Chen, J Zhang, W Wang - Placenta, 2014 - Elsevier
Introduction Prepregnancy obesity is associated with increased morbidity and mortality for
mother and offspring. The objective of our study is to estimate the effect of maternal …

Feto-placental adaptations to maternal obesity in the baboon

D Farley, ME Tejero, AG Comuzzie, PB Higgins, L Cox… - Placenta, 2009 - Elsevier
Maternal obesity is present in 20–34% of pregnant women and has been associated with
both intrauterine growth restriction and large-for-gestational age fetuses. While fetal and …