Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …

Isoorientin (ISO) is a naturally occurring C‑glycosyl flavone that has various pharmacological
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …

Isoorientin (ISO) is a flavonoid compound that can be extracted from several plant species,
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …

Ferroptosis is a newly identified type of regulated cell death that is affected by lipid
peroxidation and reactive oxygen species (ROS). In the current study, we showed that …

Cisplatin (CDDP) is a widely used chemotherapeutic agent for various solid tumors, but its
severe side effects, particularly nephrotoxicity, limit its clinical application. Isoorientin (Iso) is …

Isoorientin (ISO) is a flavonoid compound containing a luteolin structure, which can induce
autophagy in some tumor cells. This study investigated the impact of ISO in gastric cancer …

Background Chemotherapy drugs especially anthracyclines are widely used in the treatment
of hematological malignancies and solid tumors. However, their clinical application is limited …

Ferroptosis is a multi-step regulated cell death that is characterized by excessive iron
accumulation and lipid peroxidation. Cancer cells can acquire resistance to ferroptosis by …

Regulated cell death by way of ferroptosis involves iron-dependent accumulation of cellular
reactive oxygen species (ROS). Ferroptosis is attracting attention as a potential therapeutic …

Small cell lung cancer (SCLC) is a subtype of lung cancer with a very poor overall survival
rate due to its extremely high proliferation and metastasis predilection. Shikonin is an active …