Among the environmental factors that affect blood pressure, dietary sodium chloride has
been studied the most, and there is general consensus that increased sodium chloride …

Chloride (Cl−) is the major extracellular anion in the body, accompanying sodium (Na+), and
is primarily derived from dietary sources. Data suggest that increased dietary Cl− intake …

The recommendation to avoid high dietary “salt” intake for the prevention and treatment of
hypertension is often expressed in terms of dietary sodium. However, a consistent body of …

Abstract Purpose of Review Excess sodium from dietary salt (NaCl) is linked to elevations in
blood pressure (BP). However, salt sensitivity of BP varies widely between individuals and …

Recent evidence indicates that the anion accompanying sodium plays an important role in
determining the magnitude of the blood pressure increase in response to a high dietary …

Salt has played an important role in the human diet since earliest times. However, increases
in the availability and consumption of dietary salt have raised concerns that excessive …

ABSTRACT A diet high in NaCl can raise blood pressure in susceptible people and animals,
probably by similar mechanisms. The possibly harmful effects of a high-NaCl diet are not …

Excess dietary salt is a major cause of hypertension. Nevertheless, the specific mechanisms
by which salt increases arterial constriction and peripheral vascular resistance, and thereby …

Hypertension is a worldwide epidemic and its control is costly, but still inadequate. The
mechanisms underlying the development of primary hypertension remain elusive. Several …

This review examines epidemiologic, physiological, and molecular evidence that the
interplay between sodium and potassium is central to the development of hypertension. The …