We tested 16 million SNPs, identified through whole-genome sequencing of 457 Icelanders,
for association with gout and serum uric acid levels. Genotypes were imputed into 41,675 …

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory
arthritis. By combining data from> 140,000 individuals of European ancestry within the …

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease
and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a …

Over the last decade, there have been major advances in the understanding of the genetic
basis of hyperuricaemia and gout as well as of the pharmacogenetics of urate-lowering …

A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …

Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including
Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which …

Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to
identify novel genes associated with serum uric acid concentration and gout. Methods …

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of
monosodium urate crystals in and around the joints. Previous genome-wide association …

Uric acid is the end product of purine metabolism in humans and great apes, which have lost
hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 …

Gout is a common disease resulting from hyperuricemia. Recently, a genome-wide
association study identified an association between gout and a single nucleotide …