Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus
have the potential to provide near universal protection against influenza virus infection …

Circulating influenza viruses evade neutralization in their human hosts by acquiring escape
mutations at epitopes of prevalent antibodies. A goal for next-generation influenza vaccines …

Immune recognition of protein antigens relies on the combined interaction of multiple
antibody loops, which provide a fairly large footprint and constrain the size and shape of …

The influenza virus has proved an elusive target in the development of broadly protective
vaccines. A new study identifies an antibody with broad neutralizing activity against …

Understanding the natural evolution and structural changes involved in broadly neutralizing
antibody (bnAb) development holds great promise for improving the design of prophylactic …

The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention
as a potent target for universal influenza vaccines,,,–. Although the HA stalk region is …

Influenza virus can escape most antibodies with single mutations. However, rare antibodies
broadly neutralize many viral strains. It is unclear how easily influenza virus might escape …

Human monoclonal antibodies have been identified which neutralize broad spectra of
influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies …

Influenza viruses take a yearly toll on human life despite efforts to contain them with
seasonal vaccines. These viruses evade human immunity through the evolution of variants …

Pre-existing neutralizing antibody provides the first line of defence against pathogens in
general. For influenza virus, annual vaccinations are given to maintain protective levels of …