Abstract CD103+ dendritic cells (DC) are crucial for regulation of intestinal tolerance in
humans. However, upon infection of the lamina propria this tolerogenic response is …

Intestinal dendritic cells (DCs) have been shown to display specialized functions, including
the ability to promote gut tropism to lymphocytes, to polarize noninflammatory responses …

Dendritic cells (DCs) play an integral role in regulating mucosal immunity and homeostasis,
but the signaling network mediating this function of DCs is poorly defined. We identified the …

The intestinal immune system can respond to invading pathogens yet maintain immune
tolerance to self-antigens and microbiota. Myeloid cells are central to these processes, but …

Normal dynamics between microbiota and dendritic cells (DCs) support modest numbers of
T cells, yet these do not cause inflammation. The DCs that induce inflammatory T cells and …

Background Inflammatory bowel disease (IBD) pathogenesis involves an inadequately
controlled immune reaction to intestinal microbiota, and CD4+ T cells, dependent on MHC …

Introduction Immune responses in the intestines require tight regulation to avoid
uncontrolled inflammation. We previously described an innate lymphocyte population in the …

The intestinal immune system must elicit robust immunity against harmful pathogens but
must also restrain immune responses directed against commensal microbes and dietary …

Dysregulated CD4 T cell responses are causally linked to autoimmune and chronic
inflammatory disorders, yet the cellular attributes responsible for maintaining the disease …

Over the past decade, innate lymphoid cells (ILCs) have been identified as a subpopulation
of innate immune cells. These cells exist mostly in intestinal mucosal tissue and express no …