Transient enhancement of nuclear magnetism beyond thermal equilibrium is referred to as
hyperpolarization, which greatly increases the magnetic resonance (MR) signal. In …

Kidney metabolism plays a central role in the etiology of kidney disease. Metabolic
biomarkers that can differentiate and grade healthy, at-risk, and damaged tissues have …

Existing clinical markers for renal disease are limited. Hyperpolarized (HP) 13C MRI is
based on the technology of dissolution dynamic nuclear polarization (DNP) and provides …

Alterations in renal metabolism are associated with both physiological and pathophysiologic
events. The existing noninvasive analytic tools including medical imaging have limited …

Magnetic resonance imaging (MRI) is a well-established modality for assessing renal
morphology and function, as well as changes that occur during disease. However, the …

Hyperpolarized 13C MR is a novel medical imaging modality with substantially different
signal dynamics as compared to conventional 1H MR, thus requiring new methods for …

Imaging of hyperpolarized nuclei provides significant new insights into previously
inaccessible aspects of disease biology. Many of the biomolecules crucial for understanding …

Purpose: To demonstrate an increase spin‐spin relaxation time (T2) of hyperpolarized
carbon‐13 urea by nitrogen‐15 labeling its amide groups, and to show how this enables …

Editorial Dissolution dynamic nuclear polarization (dDNP) development, which involves
rapidly dissolving hyperpolarized compounds mixed with an electron paramagnetic agent …

The implementation of hyper-polarized contrast agents in MRI provides the opportunity to
combine the flexibility and safety of MR-based imaging with the large signal-to-noise …