This review addresses pharmacological, structural and functional relationships among H2-
histamine receptors and H1-histamine receptors in the mammalian heart. The role of both …

Histamine can change the force of cardiac contraction and alter the beating rate in
mammals, including humans. However, striking species and regional differences have been …

Histamine mediates a wide range of cellular responses, including allergic and inflammatory
reactions, gastric acid secretion, and neurotransmission in the central nervous system …

Histamine is highly concentrated in the heart of animals and humans. Excessive release in
pathophysiological conditions, such as immediate hypersensitivity and septic shock, causes …

We studied transgenic mice with cardiac-specific overexpression of H2-histamine receptors
(H2-TG) by using the α-myosin heavy-chain promoter. We wanted to address whether this …

In protracted myocardial ischemia, sympathetic nerve endings undergo ATP depletion,
hypoxia and pHi reduction. Consequently, norepinephrine (NE) accumulates in the …

Soon after its discovery as a component of an ergot extract, histamine was found to exert
marked effects on the cardiovascular system, hypotension and tachycardia being the most …

Norepinephrine release contributes to ischemic cardiac dysfunction and arrhythmias.
Because activation of histamine H3-receptors inhibits norepinephrine release, we searched …

The ability of five prototypic antihistamines (diphenhydramine, promethazine, cyclizine,
chlorpheniramine and tripelennamine) to modify the cardiac actions of histamine was …

Histamine is known to lead to arrhythmias in the human heart. A mouse model to mimic
these effects has hitherto not been available but might be useful to study the mechanism (s) …