It is well known that mast cells are derived from hematopoietic stem cells. However, in adult
hematopoiesis, a committed mast cell progenitor has not yet been identified in any species …

Human mast cells are known to arise from a CD34+/c-kit+ progenitor cell population that
also gives rise to neutrophils, eosinophils, basophils, and monocytes. To further characterize …

Mast cells (MC3) belong to the hemopoietic system and arise from hemopoietic precursor
cells. Human MC progenitors can be detected in the bone marrow as well as in the …

Three cornerstones of mast cell development are an absolute dependence on the presence
of stem cell factor, T-cell-independent and T-cell-dependent tissue mast cell populations …

The lineage restriction of prospectively isolated hematopoietic progenitors has been
traditionally assessed by bulk in vitro culture and transplantation of large number of cells in …

Sequential immunomagnetic isolation with 2 monoclonal antibodies was used to purify and
characterize an undifferentiated mast cell in adult mouse bone marrow that had not been …

Human mast cells are derived from CD34+ hematopoietic cells present in cord blood, bone
marrow, and peripheral blood. However, little is known about the properties of the CD34+ …

Mast cells in tissues are developed from mast cell progenitors emerging from the bone
marrow in a process highly regulated by transcription factors. Through the advancement of …

Although mast cells are hematopoietic cells, little is known about the origin of their
precursors in vivo. In this study, the origin (donor v recipient genotype) of human mast cells …

In this issue, Matsumoto et al.(1) report that histamine exocytosed from brain mast cells
(MCs) after activation by antigenic cross-linking of the high affinity IgE receptor (FcεRI) acts …